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. 2021 Oct 18;26(20):6301. doi: 10.3390/molecules26206301

Figure 5.

Figure 5

Hepatic inflammatory factor expressions in the mice fed with the liquid Lieber–DeCarli ethanol diet. (A) Immunoblotting photograph of the (B) TNF-α, (C) IL-1β, (D) IL-6, (E) NF-κB, (F) iNOS, (G) COX-2, (H) ERK1/2, (I) p-ERK/ERK1/2 ratio, (J) p38, and (K) p-p38/p38 ratio. Two groups of the mice were fed a normal diet (NOR group) or a liquid Lieber–DeCarli ethanol diet (EtOH group) without the administration of test materials. The other ethanol-induced liver injury mice were administered silymarin (200 mg/kg bw/day), a low dose of monascin (0.615 mg/kg bw/day; MS-L group), a high dose of monascin (3.075 mg/kg bw/day; MS-H group), ankaflavin (0.3075 mg/kg bw/day; AK-L group), or a high dose of ankaflavin (1.5375 mg/kg bw day; AK-H group). Data are presented as mean ± SD (n = 8). * p < 0.05, ** p < 0.01, and *** p < 0.001 vs. EtOH group. Abbreviations: TNF-α, tumor Necrosis Factor-α; IL-1β, Interleukin 1 beta; IL-6, Interleukin 6; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B; iNOS, inducible nitric oxide synthase; COX-2, cyclooxygenase-2; and ERK1/2, extracellular signal-regulated kinase 1/2.