Table 1.

Microneutralization data for equine sera collected during the immunization of the animal group, for F(ab’)₂ concentrates and for human convalescent plasma

Sample ID		PRNT50	Mean ± SD	PRNT90	Mean ± SD
	832	<16		<16
Equine	833	<16		<16
Preimmune	835	<16	16 ± 0	<16	16 ± 0
Serum	841	<16		<16
	842	<16		<16
	832	8,000		4,096
Equine serum	833	4,096		2,048
On day 28	835	64	3,660 ± 2,947	32	1,491 ± 1,655
	841	2,048		256
	842	4,096		1,024
	832	16,000		8,000
Equine serum	833	32,000		16,000
On day 35	835	512	19,302 ± 13,203	256	9,651 ± 6,601
	841	32,000		16,000
	842	16,000		8,000
	832	32,000		16,000
Equine serum	833	16,000		8,000
On day 42	835	2,048	22,809 ± 13,516	256	11,251 ± 7,055
	841	32,000		16,000
	842	32,000		16,000
	832	32,000		32,000
Equine serum	833	16,000		8,000
On day 49	835	4,096	23,219 ± 12,738	1,024	14,604 ± 11,560
	841	32,000		16,000
	842	32,000		16,000
Equine F(ab’)2 concentrate	Pilot lot	32,000		16,000
Plasma pool used in GMP production (1st immunization of Groups 1 and 2)	Pool of 2 bleedings (160 L)	16,384		4,096
GMP equine F(ab’)2 concentrate	Industrial lot (16 L API)	65,556		16,384
Human	1	512		128
Convalescent	2	128	298 ± 195	64	106 ± 36
plasma	3	256		128