Table 7.
Non-carcinogenic risk assessment results for four nitrosamines using the calculated margin of exposure (MOE).
| Nitrosamines | Synthetic Resin | EDI (mg/kg bw/day) |
BMDL10 (mg/kg bw/day) |
MOE 1) |
|---|---|---|---|---|
| NDMA | Rubber | 8.10 × 10−08 | 0.027 | 333,165 |
| TPE | 5.70 × 10−08 | 473,684 | ||
| TPU | 6.00 × 10−09 | 4,500,000 | ||
| PU | 6.00 × 10−09 | 4,500,000 | ||
| NDEA | Rubber | 1.19 × 10−07 | 0.018 | 150,963 |
| TPE | 1.14 × 10−07 | 157,895 | ||
| TPU | 1.20 × 10−08 | 1,500,000 | ||
| PU | 1.20 × 10−08 | 1,500,000 | ||
| NPYR | Rubber | 5.73 × 10−08 | 0.16 | 2,792,769 |
| TPE | 5.70 × 10−08 | 2,807,018 | ||
| TPU | 6.00 × 10−09 | 26,666,667 | ||
| PU | 6.00 × 10−09 | 26,666,667 | ||
| NMOR | Rubber | 2.99 × 10−07 | 0.7 | 2,342,976 |
| TPE | 1.14 × 10−07 | 6,140,351 | ||
| TPU | 1.20 × 10−08 | 58,333,333 | ||
| PU | 4.60 × 10−08 | 15,217,391 |
1) 10,000 or less: there is a possibility that harmful effects may occur; 10,000–100,000: the harmful effect is low; 100,000–1,000,000: there is little harmful effect; 1,000,000 or more: no harmful effects.