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. 2021 Sep 26;13(10):1936. doi: 10.3390/v13101936

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cellular immune response of recombinant RBD and S1 subunit vaccines. Twelve weeks after the boost immunization, the splenocytes isolated from RBD-hFc, RBD-mFc and S1-hFc fusion protein-immunized mice were stimulated with the RBD protein for 16 h. (A) ELISPOT was conducted to evaluate the concentration of IFN-γ secreted by splenocytes. ELISA was performed to quantify the release of IL-4 (B) and IL-10 (C) in the culture medium of splenocytes. * Significant difference compared with the control group (p < 0.05).