In the original article [1], there was a mistake in Table 2 as published. For reference Vill et al. 2019, the entry “1 in 7096” has been corrected to “1 in 7524”. Also for reference Kay et al. 2020, the entry “No” under “SMN2 Inclusion” has been corrected to say “Real-time PCR assay to assess SMN2 copy number”. The corrected Table 2 appears below. The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. The original article has been updated.
Table 2.
Reference | Region | Screening Method | SMN2 Inclusion | Number of Newborns Screened | Reported Incidence in Sample | Study Type |
---|---|---|---|---|---|---|
Chien et al. 2017 [33] | Taiwan | Real-time PCR SMN1 assay to detect homozygous exon 7 deletion; verified by droplet digital PCR assay | Droplet digital PCR assay to assess SMN2 copy number | 120,267 | 1 in 17,181 | Pilot |
Boemer et al. 2019 [32] | Belgium | Real-time PCR SMN1 assay to detect homozygous exon 7 deletion | No | Not applicable | Not applicable | Pilot |
Vill et al. 2019 [36] | Germany | Real-time PCR SMN1 assay to detect homozygous exon 7 deletion; verified by multiplex ligation-dependent probe amplification (MLPA) | MLPA to assess SMN2 copy number | 165,525 | 1 in 7524 | Pilot |
Kariyawasam et al. 2020 [34] | Australia | Real-time PCR SMN1 assay to detect homozygous exon 7 deletion | Droplet digital PCR assay to assess SMN2 copy number | 103,903 | 1 in 10,390 | Pilot |
Kay et al. 2020 [35] | New York | Real-time PCR SMN1 assay to detect homozygous exon 7 deletion | Real-time PCR assay to assess SMN2 copy number | 225,093 | 1 in 28,137 | Routine |
Footnotes
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Reference
- 1.Furnier S.M., Durkin M.S., Baker M.W. Translating Molecular Technologies into Routine Newborn Screening Practice. Int. J. Neonatal Screen. 2020;6:80. doi: 10.3390/ijns6040080. [DOI] [PMC free article] [PubMed] [Google Scholar]