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. 2021 Feb 24;6(1):e00036-21. doi: 10.1128/mSphere.00036-21

FIG 6.

FIG 6

DP and CI994 induce autophagic clearance of bacteria by enhancing the colocalization M. tuberculosis-LC3 and LC3-lysosome in human macrophages. THP-1-derived macrophages were infected with the virulent strain of M. tuberculosis expressing GFP (for 4 h) and treated with DP, CI994, and rapamycin (Rapa). (A) Distribution of colocalization of GFP-expressing M. tuberculosis and LC3 (red) in macrophages at 24 hpi. (B) Macrophages were immunostained for LC3 (green) and LysoTracker Red to detect LC3 and lysosome-containing cells.