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. 2021 Apr 19;60(19):3189–3190. doi: 10.2169/internalmedicine.6605-20

A Colon Cancer-related, Clostridium septicum-infected, Aortic Aneurysm

Masataka Kudo 1, Takayuki Uchida 2, Takahiro Sakano 3, Takashi Matono 4
PMCID: PMC8545632  PMID: 33867387

An 82-year-old Japanese woman presented with a fever and back pain. Computed tomography revealed a thoracic aortic aneurysm with periaortic gas (Picture 1) and a mass lesion in the ascending colon (Picture 2). Clostridium septicum growth was observed on blood culture, confirming infected aortic aneurysm. After 14 days of intravenous antimicrobial administration, we performed aortic replacement surgery. We also identified ascending colon cancer by colonoscopy (Picture 3) and performed laparoscopic ascending colon resection. She fully recovered from the infection after undergoing antibiotic suppressive therapy. C. septicum causes infected aortic aneurysms, which are associated with high mortality and malignancy. The 6-month mortality rate of C. septicum-infected aortic aneurysms is 79.5-100% (1,2). Malignancies have been reported as bacterial infection sources previously in 82.5% of patients with C. septicum-infected aortic aneurysms (1). Aggressive surgical interventions against infected aortic aneurysms and cancer are thus essential for a favorable outcome.

Picture 1.

Picture 1.

Picture 2.

Picture 2.

Picture 3.

Picture 3.

The authors state that they have no Conflict of Interest (COI).

Acknowledgement

We would like to thank the physicians, nurses, and clinical staff of Aso Iizuka Hospital for the high standard of care provided to the patient.

References

  • 1. Ito F, Inokuchi R, Matsumoto A, et al. Presence of periaortic gas in Clostridium septicum-infected aortic aneurysm aids in early diagnosis: a case report and systematic review of the literature. J Med Case Rep 11: 268, 2017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2. Takano H, Taniguchi K, Kuki S, Nakamura T, Miyagawa S, Masai T. Mycotic aneurysm of the infrarenal abdominal aorta infected by Clostridium septicum: a case report of surgical management and review of the literature. J Vasc Surg 38: 847-851, 2003. [DOI] [PubMed] [Google Scholar]

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