Table 5.

Sulfur microbial diet in high school and risk of early-onset (age <50 years) polyp, NHSII, 1998–2015

	Sulfur microbial diet score (median)		P trend ||
	Below	Above
Conventional adenoma	302	342
Age-adjusted OR (95% CI)†	1 [Ref]	1.15 (0.96 to 1.36)	0.02
Multivariable model 1 OR (95% CI)‡	1 [Ref]	1.13 (0.94 to 1.34)	0.04
Multivariable model 2 OR (95% CI)§	1 [Ref]	1.13 (0.95 to 1.35)	0.03
Serrated lesion	416	412
Age-adjusted OR (95% CI)†	1 [Ref]	0.98 (0.84 to 1.14)	0.54
Multivariable model 1 OR (95% CI)‡	1 [Ref]	0.96 (0.82 to 1.12)	0.31
Multivariable model 2 OR (95% CI)§	1 [Ref]	0.94 (0.81 to 1.10)	0.25

^†Adjusted for age (continuous), total caloric intake at age 13–18 (continuous), time period of endoscopy (in 2-year intervals), number of reported endoscopies (continuous), time in years since the most recent endoscopy (continuous), and reason for the current endoscopy (screening, symptoms, missing).

^‡Additionally adjusted for height (continuous), body mass index at age 18 (continuous), pack-years of smoking before age 20 (continuous), physical activity at grade 9–12 (continuous), and multivitamin use at age 13–18 (yes, no).

^§Additionally adjusted for putative colorectal cancer risk factors in mid-adulthood: body mass index (in quintiles), family history of colorectal cancer (yes, no), menopausal status (premenopausal, postmenopausal), menopausal hormone use (never, past, current use of menopausal hormones), personal history of type 2 diabetes (yes, no), pack-years of smoking (never, 0.1–19.9, ≥20 pack-years), physical activity (in metabolic equivalent of task-hours/week, quintiles), current use of multivitamin (yes, no), regular use of aspirin (yes, no), and regular use of non-steroidal anti-inflammatory drugs (yes, no).

^||Calculated using the median of each quantile as a continuous variable

Abbreviations: CI (confidence interval), OR (odds ratio)