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. 2021 Jun 26;160(4):1442–1458. doi: 10.1016/j.chest.2021.06.028

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

A-C, Prognostic value of NE in United Kingdom validation cohorts. A, Kaplan-Meier estimates of 5-year survival according to NE tertile in validation cohort A (T1, < 2.545 RFU; T2, 2.545-2.623 RFU; T3, > 2.623 RFU) and by NE quartile in cohort B (Q1, < –0.557 log RFU; Q2, –0.557 to 0.200 log RFU; Q3, 0.200-0.796 log RFU; and Q4, > 0.796 log RFU, z-scored relative to healthy control participants). B, Plots showing the nonlinear relationship between NE and mortality risk in validation cohorts A (left) and B (right), reflecting bootstrapped estimates from cubic spline Cox regression models. Prognostic thresholds are indicated (maroon points). C, Survival curves are displayed for subgroups dichotomized by the prognostic NE threshold identified in each cohort. NE = neutrophil elastase; Q = quartile; RFU = relative fluorescent unit; T = tertile.