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. 2021 Sep 7;12(5):e01969-21. doi: 10.1128/mBio.01969-21

FIG 6.

FIG 6

Enhanced macrophage activation modestly compensates for the requirement for microglia in Lyz2-DP1−/− mice. Mice were fed PLX5622-containing or control chow either at the time of infection (group 1) or 3 days prior to infection (group 2). (a to d) Group 1 mice were fed PLX5622 chow on the day of rJHMV infection. (b) A log rank Mantel-Cox test was used to analyze survival differences between PLX5622-treated WT and Lyz2-DP1−/− mice. (c and d) Clinical scores and weights. Data represent pooled results from 2 experiments with 8 to 10 mice per group. A Mann-Whitney U test was used to analyze differences in weight (days 6 to 11) (P < 0.05) (d) and clinical score (days 9 to 12) (P < 0.05) (c) data. (e to h) Lyz2-DP1−/− mice received PLX5622 chow before infection. Survival (f), clinical scores (g), and weights (h) are shown. A Mann-Whitney U test was used to analyze weight (days 8 to 11) (P < 0.05) (h) and clinical score (days 8 to 11) (P < 0.05) (g) data. Data are representative of pooled results from 2 experiments with 6 to 7 mice in each group.