TABLE 1.
Summary of previously published data on toxin specificity
| Toxin | Family or superfamily | Ribosome dependence | Core cleavage specificitya |
|---|---|---|---|
| MazF | MazF (4) | No (19, 39) | ^ACA[AUC] (19, 39) |
| ChpB | MazF (4, 40) | No (40) | ^A^C[UGC] (40) |
| RnlA | RnlA, sometimes fused to RNase HI domains (41) | Unknown (41) | Poorly defined (41) |
| HicA | HicA (27) | No (27) | Poorly defined (27) |
| MqsR | RelE (structural homology) (31, 32), GinB (4) | No (17, 20, 42), possible ribosome interaction (32) | G^CU (17, 20, 42) |
| RelE | RelE (4) | Yes (16) | C^G (16); coding frame preference, 12^3 (16) |
| YhaV | RelE (43) | Yes (44), No (43) | Poorly defined (44) |
| HigB | RelE (4) | Yes (31) | Poorly defined (31) |
| YoeB | RelE (4) | Yes (45) | ^[AG] (46) |
| YafO | YafO (4), RelE (weak sequence and structural homology) (31) | Yes (31) | Poorly defined (31) |
| YafQ | RelE (4) | Yes (47, 48) | AA^A (48), ^A (47); coding frame preference 12^3 (47, 48) |
a
A ^ indicates site of cleavage; brackets indicate motif may include any of the listed nucleotides at that site.