FIG 10.

Global overview of C. albicans response to hydrogen peroxide according to the results from this work. Oxidative damage in proteins started with the increase in ROS accumulation, which triggered an antioxidant response with the increase of proteins from main detoxification systems (catalase, glutathione, and thioredoxin). The increase of antioxidant proteins was less remarkable than at the higher concentration of hydrogen peroxide (10 mM) leading to the accumulation of oxidized proteins. This effect joined to the lower activity of the proteasome observed at 10 mM than at 5 mM hydrogen peroxide led to mitochondrial damage and an increase in apoptosis percentage in 10 mM hydrogen peroxide. The thicknesses of lines indicate the activation of each process. Adapted from the work of Costa et al. (57).