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. 2021 Sep 24;10:e58313. doi: 10.7554/eLife.58313

Figure 4. Echocardiographic analyses of wild-type (WT) and myopalladin knockout (MKO) mice following transaortic constriction (TAC).

Figure 4.

(A–H) Echocardiography analyses of WT and MKO male mice under basal conditions and 1, 2, and 4 weeks after TAC. Pressure gradient >70 mmHg. LVID, left ventricular inner diameter; FS, fractional shortening; EF, ejection fraction; LVPW, left ventricular posterior wall thickness; IVS, interventricular septum thickness; RWT, relative wall thickness ((LVPWd + IVSd)/LVIDd); CO, cardiac output; d, diastole; s, systole. Data are represented as mean ± standard error of the mean (SEM) (n = 8–19 per group). **p < 0.01; ***p < 0.001; linear mixed model (LMM) with Bonferroni’s multiple comparison test. (I) Representative echocardiographic short-axis M-mode images from hearts of WT and MKO male mice under basal conditions and 1 and 4 weeks after TAC. (J–L) Body weight (BW) (J), heart weight (HW) (K), and heart weight to body weight ratio (HW/BW) (L) of WT and MKO male mice 4 weeks after TAC or SHAM surgery. Data are represented as mean ± SEM (n = 9–11 per group). **p < 0.01; ***p < 0.001; two-way analysis of variance (ANOVA) with Bonferroni’s multiple comparison test.

Figure 4—source data 1. Echocardiographic parameters of 8-week-old wild-type (WT) and myopalladin knockout (MKO) male mice before and after transaortic constriction (TAC).
Figure 4—source data 2. Echocardiographic analysis on wild-type (WT) and myopalladin knockout (MKO) male mice subjected to transaortic constriction (TAC) or SHAM.
Figure 4—source data 3. Measurements of heart weight to body weight ratio (HW/BW) in wild-type (WT) and myopalladin knockout (MKO) male mice subjected to transaortic constriction (TAC) or SHAM.