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. 2021 Oct 21;65(6):1123–1145. doi: 10.1007/s11427-020-1959-5

Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities

Lu Luo 1, Jun Yang 1, Cheng Wang 2, Jie Wu 1, Yafang Li 3, Xu Zhang 4, Hui Li 5, Hui Zhang 6, Yumei Zhou 7, Aiping Lu 8, Shilin Chen 1,✉
PMCID: PMC8548270  PMID: 34705221

Abstract

As coronavirus disease 2019 (COVID-19) threatens human health globally, infectious disorders have become one of the most challenging problem for the medical community. Natural products (NP) have been a prolific source of antimicrobial agents with widely divergent structures and a range vast biological activities. A dataset comprising 618 articles, including 646 NP-based compounds from 672 species of natural sources with biological activities against 21 infectious pathogens from five categories, was assembled through manual selection of published articles. These data were used to identify 268 NP-based compounds classified into ten groups, which were used for network pharmacology analysis to capture the most promising lead-compounds such as agelasine D, dicumarol, dihydroartemisinin and pyridomycin. The distribution of maximum Tanimoto scores indicated that compounds which inhibited parasites exhibited low diversity, whereas the chemistries inhibiting bacteria, fungi, and viruses showed more structural diversity. A total of 331 species of medicinal plants with compounds exhibiting antimicrobial activities were selected to classify the family sources. The family Asteraceae possesses various compounds against C. neoformans, the family Anacardiaceae has compounds against Salmonella typhi, the family Cucurbitacea against the human immunodeficiency virus (HIV), and the family Ancistrocladaceae against Plasmodium. This review summarizes currently available data on NP-based antimicrobials against refractory infections to provide information for further discovery of drugs and synthetic strategies for anti-infectious agents.

Supporting Information

The supporting information is available online at 10.1007/s11427-020-1959-5. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

Keywords: natural product, infectious pathogen, drug discovery, drug development, in silico analysis

Electronic Supplementary Materials

11427_2020_1959_MOESM1_ESM.pdf (4.5MB, pdf)

Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities

Acknowledgements

This work was supported by the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences (CI2021A04013) and the Fundamental Research Funds for the Central Public Welfare Research Institutes (L2021029). The authors thank Jiqing Zhang, Qin Huang, Qianwen Liu, Dr.Naishi Li, Prof. Haoyu Hu, Dr. Jimeng Zhao, and Dr. Lei Fan for their contributions to this article.

Footnotes

Compliance and ethics

The author(s) declare that they have no conflict of interest.

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Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities

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