Abstract
Objective
To identify clinical and laboratory features that differentiate dengue fever patients from MIS-C patients and determine their outcomes.
Methods
This comparative cross-sectional study was done at a tertiary care teaching institute. We enrolled all hospitalized children aged 1 month–18 years and diagnosed with either MIS-C and/or dengue fever according to WHO criteria between June and December, 2020. Clinical and laboratory features and outcomes were recorded on a structured proforma.
Results
During the study period 34 cases of MIS-C and 83 cases of Dengue fever were enrolled. Mean age of MIS-C cases (male, 86.3%) was 7.89 (4.61) years. MIS-C with shock was seen in 15 cases (44%), MIS-C without shock in 17 cases (50%) and Kawasaki disease-like presentation in 2 cases (6%). Patients of MIS-C were younger as compared to dengue fever (P=0.002). Abdominal pain and erythematous rash were more common in dengue fever. Of the inflammatory markers, mean C reactive protein was higher in MIS-C patients [100.2 (85.1) vs 16.9 (29.3) mg/dL] (P<0.001). In contrast, serum ferritin levels were higher in dengue fever patients (P=0.03). Mean hospital stay (patient days) was longer in MIS- C compared to dengue fever (8.6 vs 6.5 days; P=0.014).
Conclusions
Clinical and laboratory features can give important clues to differentiate dengue fever and MIS-C and help initiate specific treatment.
Electronic Supplementary Material
Supplementary material is available in the online version of this article at 10.1007/s13312-021-2329-9.
Keywords: Diagnosis, Evaluation, Inflammatory markers, Management
Electronic Supplementary Material
Acknowledgements
Namita Bansal, Statistician for analyzing the data and for preparation of tables and graphs. Dr Jatinder Goraya for his advice and support.
Footnotes
Note
Additional material related to this study is available with the online version at u]www.indianpediatrics.net
Ethics clearance
Institutional ethics committee; No: DMCH/R&D/2020/168 dated November 09, 2020.
Contributors
GSD, PAP: conceived and designed the study: SK, NG, KG: recruited the subjects, collected the data; KA, SB, GSD: literature review, initial draft of manuscript; PAP, DB, GSD: contributed to manuscript writing; and PAP, DB, GSD: finalized the manuscript. All authors approved the manuscript submitted.
Funding
None
Competing interests
None stated.
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