Table 5:
Key Results Summary Table
| Endpoint | PFOA effects | PFOS effects | PFHxS effects | PFAS Mix effects | HFD effects | PFAS+HFD combined effects | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| Dams | Litter Size | ↓ w/ PFOA | |||||
| BW (PND 21) | ↑ | ↑ | |||||
| Liver Weight | ↑ | ↑ | |||||
| Serum ALT | ↑ | ↓ w/ PFOA | |||||
| Liver TAG | ↓ | ↑ | |||||
| Liver Cholesterol | ↑ | ||||||
| Serum PFAS | ↓ PFOS | ↑ PFOS | |||||
|
| |||||||
| Pups (PND 21) | Male BW | ↑ | |||||
| Female BW | ↓ | ↑ | |||||
| Liver Weight | ↑ | ↑ | |||||
| Liver Histopathology | ↑ | ||||||
| Total Liver Lipid | ↑ | ||||||
| Liver TAG | ↑ | ↑ | ↑ | ↑ | ↑ | ↓ w/ all PFAS | |
| Liver Cholesterol | ↓ | ||||||
| Serum ALT | ↑ | ↑ | ↓ w/ all PFAS | ||||
| Serum Leptin | ↑ | ↓ w/ all PFAS | |||||
| Male Serum Adiponectin | ↑ | ↑ | |||||
| Female Serum Adiponectin | ↓ | ||||||
| Serum PFAS | ↓ PFOA | ↓ PFOS | |||||
| Liver PFAS | ↓ PFOA | ↓ PFOS | |||||
|
| |||||||
| Pups (PND 90) | Male BW | ↑ | |||||
| Female BW | ↑ | ||||||
| Male Liver Weight | ↑ | ↑ | |||||
| Female Liver Weight | ↑ | ↑ | |||||
| Male Serum ALT | ↑ | ↓ w/ all PFAS | |||||
| Female Serum ALT | ↑ | ||||||
| Female GHbA1c | ↑ | ||||||
| Male Serum Leptin | ↑ | ↑ | ↑ | ||||
| Female Serum Leptin | ↑ | ||||||
| Male Serum Adiponectin | ↑ | ↑ | |||||
| Female Serum Adiponectin | ↑ | ↑ | |||||
| Male Serum PFAS | ↑ PFOA | ||||||
| Female Serum PFAS | ↑ PFOA verse Male | ↑ all PFAS | |||||