Table 2.
Top 20 DMCs, grouped by adipogenesis stage
| OD vs OND | CpG ID | OND Beta mean | OD Beta mean | Delta Beta | Chromosome | Gene symbol | Genomic region | P value |
|---|---|---|---|---|---|---|---|---|
| MSC | cg02332293 | 0.710 | 0.889 | 0.180 | 5 | IGR | 7.44E-08 | |
| cg26480858 | 0.305 | 0.201 | 0.103 | 7 | THSD7A | Body | 7.42E-05 | |
| cg05170452 | 0.713 | 0.829 | 0.115 | 5 | IGR | 9.31E-05 | ||
| cg16626954 | 0.513 | 0.406 | 0.107 | 3 | IGR | 0.00015 | ||
| cg24056885 | 0.500 | 0.356 | 0.144 | 3 | ABCC5AS1 | TSS200 | 0.00015 | |
| cg12771637 | 0.555 | 0.657 | 0.101 | 11 | IGR | 0.00021 | ||
| cg25635251 | 0.531 | 0.664 | 0.133 | 11 | IGR | 0.00028 | ||
| cg13482309 | 0.393 | 0.571 | 0.178 | 9 | OR1B1 | 1stExon | 0.00028 | |
| cg18830697 | 0.747 | 0.849 | 0.102 | 6 | RIMS1 | TSS200 | 0.00052 | |
| cg11086466 | 0.762 | 0.608 | 0.154 | 6 | RNF182 | 5’UTR | 0.00054 | |
| cg18454042 | 0.581 | 0.694 | 0.113 | 7 | SDK1 | Body | 0.00063 | |
| cg18116804 | 0.525 | 0.368 | 0.156 | 10 | PLXDC2 | Body | 0.00064 | |
| cg18860301 | 0.634 | 0.466 | 0.168 | 6 | RNF182 | 5’UTR | 0.0007 | |
| cg06121514 | 0.576 | 0.677 | 0.101 | 15 | IPW | Body | 0.00071 | |
| cg14439102 | 0.544 | 0.442 | 0.102 | 9 | GNAQ | Body | 0.00075 | |
| cg06104343 | 0.761 | 0.631 | 0.130 | 17 | IGR | 0.00082 | ||
| cg03915559 | 0.592 | 0.455 | 0.136 | 10 | LGI1 | Body | 0.00082 | |
| cg00435063 | 0.449 | 0.553 | 0.104 | 7 | PTPRN2 | Body | 0.0009 | |
| cg10284704 | 0.773 | 0.645 | 0.128 | 15 | IGR | 0.0009 | ||
| cg03962019 | 0.799 | 0.689 | 0.110 | 1 | IGR | 0.00095 | ||
| PreA | cg17292337 | 0.092 | 0.351 | 0.258 | 12 | IGR | 1.62E-05 | |
| cg20790798 | 0.456 | 0.611 | 0.156 | 5 | IGR | 1.99E-05 | ||
| cg24517467 | 0.444 | 0.602 | 0.158 | 7 | IGR | 2.12E-05 | ||
| cg14950747 | 0.915 | 0.796 | 0.118 | 19 | ZFR2 | Body | 7.18E-05 | |
| cg24449463 | 0.480 | 0.280 | 0.200 | 1 | DCAF6 | Body | 9.36E-05 | |
| cg23084986 | 0.748 | 0.645 | 0.103 | 1 | RAB42 | TSS1500 | 0.00011 | |
| cg07415266 | 0.562 | 0.686 | 0.124 | 2 | IL18RAP | Body | 0.00017 | |
| cg27216788 | 0.266 | 0.459 | 0.193 | 16 | ST3GAL2 | 3’UTR | 0.00025 | |
| cg06821828 | 0.262 | 0.548 | 0.286 | 14 | IGR | 0.00026 | ||
| cg20253542 | 0.872 | 0.718 | 0.155 | 7 | IGR | 0.00026 | ||
| cg06259934 | 0.48 | 0.322 | 0.162 | 10 | ZMIZ1 | Body | 0.0003 | |
| cg02721751 | 0.837 | 0.651 | 0.186 | 6 | SLC44A4 | Body | 0.00032 | |
| cg27614534 | 0.855 | 0.710 | 0.145 | 18 | ALPK2 | TSS1500 | 0.00035 | |
| cg07342647 | 0.847 | 0.669 | 0.178 | 16 | IGR | 0.00041 | ||
| cg04051335 | 0.641 | 0.479 | 0.162 | 5 | C5orf62 | TSS1500 | 0.00045 | |
| cg17071479 | 0.736 | 0.608 | 0.128 | 16 | SRL | Body | 0.00046 | |
| cg26457868 | 0.495 | 0.340 | 0.155 | 10 | SUFU | Body | 0.00053 | |
| cg17045772 | 0.859 | 0.738 | 0.122 | 1 | CTPS | TSS1500 | 0.00053 | |
| cg15397200 | 0.618 | 0.738 | 0.119 | 2 | IGR | 0.00053 | ||
| cg05867245 | 0.563 | 0.872 | 0.310 | 20 | ZBTB46 | Body | 0.00055 | |
| MA | cg22960347 | 0.361 | 0.247 | 0.115 | 7 | IGR | 7.03E05 | |
| cg00216549 | 0.631 | 0.529 | 0.102 | 1 | DDAH1 | Body | 0.00011 | |
| cg05146544 | 0.109 | 0.227 | 0.118 | 2 | IGR | 0.00023 | ||
| cg24224080 | 0.331 | 0.220 | 0.111 | 5 | IGR | 0.00026 | ||
| cg24449463 | 0.451 | 0.310 | 0.140 | 1 | DCAF6 | Body | 0.00029 | |
| cg10354380 | 0.573 | 0.458 | 0.115 | 6 | IL17F | TSS200 | 0.00032 | |
| cg01911494 | 0.290 | 0.177 | 0.113 | 16 | LMF1 | Body | 0.00049 | |
| cg27082921 | 0.803 | 0.655 | 0.147 | 19 | ATP8B3 | Body | 0.00053 | |
| cg11613005 | 0.340 | 0.443 | 0.103 | 5 | GPR151 | 1stExon | 0.00068 | |
| cg19534681 | 0.120 | 0.237 | 0.117 | 2 | IGR | 0.00073 | ||
| cg17487381 | 0.391 | 0.272 | 0.119 | 9 | IGR | 0.00098 | ||
| cg25635251 | 0.497 | 0.652 | 0.156 | 11 | IGR | 0.00099 | ||
| cg23989344 | 0.719 | 0.591 | 0.128 | 10 | ST8SIA6 | Body | 0.00107 | |
| cg00034755 | 0.785 | 0.678 | 0.107 | 22 | IGR | 0.00114 | ||
| cg22891588 | 0.700 | 0.594 | 0.105 | 5 | LRRC70 | 1stExon | 0.00131 | |
| cg04676645 | 0.820 | 0.704 | 0.116 | 8 | CLU | Body | 0.00166 | |
| cg16246747 | 0.722 | 0.607 | 0.115 | 2 | ACOXL | 5’UTR | 0.00176 | |
| cg00945409 | 0.400 | 0.222 | 0.177 | 10 | ZMIZ1AS1 | Body | 0.0019 | |
| cg19868364 | 0.560 | 0.663 | 0.103 | 14 | IGR | 0.00203 | ||
| cg06159404 | 0.188 | 0.352 | 0.164 | 10 | IGR | 0.00217 |
DMC: differential methylation CpG sites,
Transcription starts sites (TSS 200 pb1500 pb), intergenic regions (IGR)