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. 2021 Apr 13;144(9):2625–2634. doi: 10.1093/brain/awab147

Figure 3.

Figure 3

Inter-autoimmunity classifiers characterizing distinct neuro-inflammatory diseases. (A) Prediction accuracy and AUC of plasma cell occurrence and intrathecal IgG synthesis as determined by logistic regression for differentiating early RRMS, including radiologically or clinically isolated syndrome (RIS/CIS) from NMOSD (yellow triangle), Susac syndrome (SuS, pink triangle) and AIE (blue triangle). (B) Composite score (top left) derived by addition of plasma cell positivity (=1) and intrathecal IgG synthesis (=1) allowing differentiation (top right) of patients with RRMS in the discovery cohort from patients with NMOSD, Susac syndrome and AIE by a cut-off of 1.5 as determined by ROC analysis (top left) with an AUC of 84.0 and an OR of 18.9. Inter-autoimmunity classification was verified in the validation cohort, showing classification with an odds ratio of 35.8 (bottom left). (C) Inter-autoimmunity classifiers distinguishing RRMS from other neuroinflammatory autoimmune diseases.