Abstract
Amprolium fed to growing chickens in a concentration of 125 p.p.m. in a commercial diet was accompanied by a small but significant decrease in thyroid activity compared with the results for untreated chickens, judged by serum PBI values. The epithelium : colloid relation was lowered. This was presumed to be a consequence of the antagonistic effect of amprolium on thiamine. Payzone feeding, 10 p.p.m. in commercial feed, caused a more pronounced retardation of thyroid activity, judged by the same criteria. A possible connection between the depressed thyroid function and the well-established improvement in weight gain and feed conversion in connection with payzone feeding is discussed.
Keywords: amprolium, payzone, thyroid
Sammanfattning
Amprolium, 125 p.p.m. i kommersiellt foder, orsakade hos växande kycklingar en lindrig men signifikant (P< 0.001) sänkning i serum PB J. Histologiskt förelåg en sänkt epitel:kolloid-relation i sköldkörteln. Amproliums thiaminantagonistiska effekt förmodas vara orsaken till en minskning i sköldkörtelns aktivitet.
Payzone, 10 p.p.m. i samma basfoder, gav en kraftigare sänkning av serum-PBJ och epitel:kolloid-relation. Ett eventuellt samband mellan en sänkt sköldkörtelaktivitet och den väldokumenterade förbättringen i viktökning och foderutnyttjande i samband med payzoneutfodring diskuteras.
Full Text
The Full Text of this article is available as a PDF (403.5 KB).
References
- Andersson, P.: Effekten av kontinuerlig utfodring med Amprolium resp. Zoalen på sköldkörtelns status hos växande kycklingar. (The effect of continued feeding of Amprolium resp. Zoalene on the functional state of the thyroid in growing chicks). Proc. XI. Nord. Vet. Congr., Bergen 1970, 37–40.
- Cyanamid Ltd. : Payzone, growth promoting agent for chickens. Technical information. London 1968.
- Gerlach H. Zum Verhalten der Darmflora bei Mastküken nach nutritiver Dosierung von Nitrovin. (The behaviour of the intestinal flora in chickens after nutritional administration of Nitrovin) Dtsch. tierärztl. Wschr. 1970;77:562–565. [PubMed] [Google Scholar]
- Olivier A H, Stubbs O J, Liebenberg C B. Influence of coccidiostats on certain physiological processes of the growing fowl. S.Afr. J. agric. Sci. 1966;9:917–926. [Google Scholar]
- Ott W H, Dickinson A M, van Iderstine A. Amprolium 3. Tolerance studies in chickens. Poultry Sci. 1960;39:1280–1281. [Google Scholar]
- Ringer, R. K.: Avian Physiology. ed. P. D. Sturkie, 2nd Ed., Cornell Univ. Press 1965, 627.