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. 1973 Jun 1;14(2):233–244. doi: 10.1186/BF03547441

On the Ultrastructure of Epithelial Cells in Bile Ducts of Cattle Chronically Infected with Fasciola Hepatica

Gallgångsepitelets ultrastruktur hos nötkreatur med kronisk infektion av Fasciola hepätica

Timo Rahko 1,✉
PMCID: PMC8559891  PMID: 4728104

Abstract

This paper describes briefly the normal ultrastructure of bile-duct epithelial cells in cattle and the main ultrastructural alterations produced in them by chronic infection with Fasciola hepatica. The studies showed only inconsiderable abnormalities in the ultrastructure of the epithelium in infections of a low degree as also during the recovery phase of the disease. On the other hand, in heavily infected livers pronounced ultrastructural alterations were seen in the surface epithelium of the main intrahepatic bile ducts invaded by the flukes. In such areas the intercellular spaces were filled with dense homogeneous material, and intact desmosomes and junctional complexes were not regularly seen, which indicates that foreign material may leak into the bile. The extracellular material was probably composed of albumin, and the significance of the present results regarding the etiology of hypoalbuminaemia during chronic fascioliasis is discussed.

Keywords: electron microscopy, bile ducts, fascioliasis, cattle

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Footnotes

Supported by grants from the National Research Council for Medical Sciences and the Finnish Veterinary Medical Foundation.

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