Prognostic Value of Blood Urea Nitrogen to Serum Albumin Ratio in Intensive Care Unit Patients with Lung Cancer

Abstract

Background

We aimed to evaluate the prognostic ability of blood urea nitrogen (BUN) to serum albumin ratio (BAR) to predict in-hospital mortality in patients with lung cancer in the intensive care unit (ICU).

Methods

Medical Information Mart for Intensive Care IV (MIMIC-IV v1.0) database was used to identify patients who were diagnosed with lung cancer. The primary outcome was in-hospital mortality. Multivariate COX regression was used to investigate the association between BAR and in-hospital mortality and propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were also used to ensure the robustness of our findings. eICU-CRD database (validation cohort) was also applied to validate our findings.

Results

The optimal cut-off value for BAR was 6.8mg/g. Among 1202 patients who were diagnosed with lung cancer, 287 high-BAR group (≥6.8mg/g) patients and 287 low-BAR group (<6.8mg/g) patients, who had similar propensity scores were included in this study. After matching, the high-BAR group had significantly higher in-hospital mortality (hazard ratio, HR, 2.24, 95% confidence index, 95% CI, 1.57–3.19, P<0.001) even after adjustment for confounding factors. Moreover, the performance of BAR was superior to that of BUN and serum albumin alone and could add net benefit in predicting in-hospital mortality. Those results were further confirmed in the validation cohort.

Conclusion

As an easily accessible and cost-effective parameter, BAR could serve as a good prognostic predictor for lung cancer patients in ICU.

Introduction

Despite great progress in our understanding of risk, development, and treatment options, lung cancer, which usually consists of small cell lung cancer and non-small cell lung cancer, remains one of the most common diagnosed cancers and the leading cause of cancer-related death worldwide.^1–4 Due to the nature of the disease and the aggressive treatments, lung cancer patients usually require admission to intensive care units (ICU) for invasive monitoring or treatment.^5–7 Compared with other solid tumors, lung cancer patients admitted to ICU tend to have one of the poorest ICU and in-hospital survival rates.^8–10 Hence, it is essential for clinicians to identify lung cancer patients at high risk of mortality.

Serum albumin is one of the most familiar nutritional indexes and has been demonstrated to be a prognostic factor for different types of cancers.^11–14 Blood urea nitrogen (BUN) is an important parameter reflecting the relationship between kidney condition and nutritional status of patients and has also been found to be associated with mortality.¹⁵ Moreover, the combination of serum albumin and bun, bun to serum albumin ratio (BAR), which is calculated from the quotient between BUN and albumin, was introduced as an important predictor of mortality in various diseases, including gastrointestinal bleeding, community-acquired pneumonia and so on.^16–18 However, to the best of our knowledge, no study has been constructed to investigate the association between BAR and in-hospital mortality for critical care patients with lung cancer. Hence, in the current study, we initially investigated the correlation between BAR and prognosis of ICU patients with lung cancer using data from the Medical Information Mart for Intensive Care IV (MIMIC-IV version 1.0) database. Then, propensity score matching (PSM) and propensity score-based inverse probability of treatment weighting (IPTW) was introduced to ensure the robustness of our results, we further verified this finding in another big public database (eICU Collaborative Research Database, eICU-CRD v2.0).

Materials and Methods

Study Population

We obtained data from the MIMIC IV database and eICU-CRD database in accordance with the ethical standards of the Institutional Review Board (IRB) of the Massachusetts Institute of Technology (MIT). eICU-CRD contains data of more than 200 thousand ICU admissions in 2014 and 2015 at 208 US hospitals while MIMIC-IV includes information of more than 70,000 patients admitted to the ICUs of Beth Israel Deaconess Medical Center in Boston, MA, from 2008 to 2019.^19,20 This study was conducted in accordance with the Helsinki Declaration and authors had successfully accomplished the National Institutes of Health’s (NIH) online training course and the Protection of Human Research Participants Examination and got permission to extract data from MIMIC IV and eICU databases. Moreover, the study protocol was reviewed and successfully approved by the Ethics Committee of the Second Affiliated Hospital of Jianghan University. Considering that this was a retrospective study and all patients in this study were extracted from public database, informed consent was waived.

Selection of Participants

Adult patients who were diagnosed with lung cancer based on the ninth or tenth revision of International Classification of Diseases (ICD-9/10) code during their admissions were included in this study. Moreover, for patients readmitted to the ICU, only the first ICU and first hospital admissions were included in this study. We also excluded patients with missing bun or serum albumin or who spent less than 48 hours in the ICU (Figure 1).

Figure 1.

Study flow diagram of the present study.

Variable Extraction

Baseline characteristics and admission information: age, gender, weight, tumor type, and severity score measured by the sequential organ failure assessment (SOFA) score, the Oxford acute severity of illness score (OASIS), acute physiology score III (APSIII) and the Charlson comorbidity score were calculated as described in previous studies.^21–24 Comorbidities including hypertension, diabetes, chronic kidney disease (CKD), congestive heart failure (CHF), myocardial infarct and liver disease were also collected for analysis based on the (ICD-9/10) codes. Complications including sepsis based on sepsis 3.0 criteria,²⁵ acute kidney injury based on KDIGO guideline in 48 hours,²⁶ acute heart failure (AHF) and acute respiratory failure (ARF) based on ICD codes were also included in this study. Use of mechanical ventilation (MV), vasopressors and renal replacement therapy during their hospital stay were also recorded in this study. Moreover, initial vital signs and laboratory results were also extracted by structured query language with PostgreSQL 9.6.

The BAR (mg/g) was calculated by initial serum BUN (mg/dL) /serum albumin (g/dL).

The primary outcome in this study was in-hospital mortality.

Statistical Analyses

Continuous variables were expressed as mean (standardized mean difference, SMD), categorical covariates were reported as number (percentage). X-tile software (version 3.6.1) was applied to determine the best cutoff values for BAR in MIMIC-IV database. Then, clinical features between high BAR and low BAR groups were analyzed with either Student’s t-test or Chi-squared test as appropriate. Propensity score matching (PSM) and propensity score-based inverse probability of treatment weighting (IPTW) were also applied to adjust the imbalance of the covariates between two groups to ensure the robustness of our results. One-to-one nearest neighbor matching with a caliper width of 0.2 was applied in the current study. Multivariate COX regression and adjusted hazard ratio (HR) were also conducted in the original cohort, matched cohort, weighted cohort and validation cohort to investigate the association between BAR and in-hospital mortality. Receiver operating characteristic curve (ROC) was used to compare the predictive performance of BAR, BUN and albumin in predicting in-hospital mortality in different cohorts. Finally, the decision curve analysis (DCA) was also performed to evaluate the potential clinical usefulness and benefits of the GLR. All analyses were performed using R (version 4.1.0) and X-tile (version 3.6.1) software and p<0.05 was considered statistically significant.

Results

Patient Clinical Features

A total of 2209 patients (1202 patients in the original cohort, 1007 patients in the validation cohort) with lung cancer were analyzed in this study. The best cut-off value for BAR, determined using X-tile software, was 6.8mg/g. We grouped the patients according to the measurements of BAR. In the original cohort, compared to patients with low BAR (<6.8mg/g), those with high BAR were older, higher proportion of males, had metastatic cancer and interventions during hospital stay, had more comorbidities and complications, had higher levels of severity scores, total bilirubin, white blood counts, anion gap, creatinine and potassium, and lower level of mean arterial pressure (MAP), hemoglobin, platelets and bicarbonate. Moreover, patients in high BAR group had prolonged ICU stays and higher in-hospital mortality. After PSM and IPTW, almost all covariates in the matched cohort and in the weighted cohort were balanced between two groups (Supplemental Figure 1). Moreover, patients in the validation cohort exhibited similar characteristics to those in the original cohort (Table 1).

Table 1.

Comparisons of Baseline Characteristics Between the Original Cohort, Matched Cohort, and Validation Cohort

Covariates	Original Cohort			Matched Cohort			Validation Cohort
	Low BAR	High BAR	P	Low BAR	High BAR	P	Low BAR	High BAR	P value
N	621	581	–	287	287	–	496	511	–
Age, years	64.7 (12.0)	69.7(12.2)	<0.001	67.8 (11.7)	67.9 (12.0)	0.941	64.5 (11.5)	69.2 (11.2)	<0.001
Gender, male, n (%)	296 (47.7)	339 (58.3)	<0.001	15 (54.4)	160 (55.7)	0.801	238 (48.0)	282 (55.2)	0.026
Weight (kg)	71.7 (19.3)	75.7 (20.0)	0.001	73.5 (19.6)	73.3 (19.3)	0.886	73.8 (21.3)	76.1 (21.3)	0.088
Tumor type, n (%)			0.001			0.866			0.238
Primary	371 (59.7)	290 (49.9)		162 (56.4)	159 (55.4)		380 (76.6)	374 (73.2)
Metastatic	250 (40.3)	291 (50.1)		125 (43.6)	128 (44.6)		116 (23.4)	137 (26.8)
Interventions, n (%)
MV	436 (70.2)	355 (61.1)	0.001	186 (64.8)	190 (66.2)	0.792	280 (56.5)	345 (67.5)	<0.001
CRRT	4 (0.6)	15 (2.6)	0.014	3 (1.0)	3 (1.0)	1.000	1 (0.2)	4 (0.8)	0.388
Vasopressors	121 (19.5)	211 (36.3)	<0.001	79 (27.5)	77 (26.8)	0.925	78 (15.7)	144 (28.2)	<0.001
Score system
SOFA	3.4 (1.2)	5.8 (1.6)	<0.001	4.4 (1.1)	4.5 (1.8)	0.821	2.9 (1.2)	4.8 (1.1)	<0.001
OASIS	31.1 (8.0)	34.5 (9.0)	<0.001	32.5 (8.3)	32.4 (7.9)	0.935	24.4 (10.3)	27.8 (10.1)	<0.001
APSIII	41.0 (10.4)	60.5 (14.5)	<0.001	48.9 (19.3)	48.9 (15.9)	0.989	41.4 (18.9)	54.6 (24.2)	<0.001
Comorbidities, n (%)
Hypertension	259 (41.7)	220 (37.9)	0.193	133 (46.3)	125 (43.6)	0.557	84 (16.9)	92 (18.0)	0.716
Diabetes	88 (14.2)	152 (26.2)	<0.001	56 (19.5)	53 (18.5)	0.831	84 (16.9)	133 (26.0)	0.001
CKD	40 (6.4)	161 (27.7)	<0.001	36 (12.5)	35 (12.2)	1.000	21 (4.2)	61 (11.9)	<0.001
Myocardial infarct	38 (6.1)	69 (11.9)	0.001	26 (9.1)	26 (9.1)	1.000	39 (7.9)	40 (7.8)	1.000
CHF	68 (11.0)	136 (23.4)	<0.001	49 (17.1)	43 (15.0)	0.569	39 (7.9)	71 (13.9)	0.003
COPD	222 (35.7)	212 (36.5)	0.836	100 (34.8)	96 (33.4)	0.792	171 (34.5)	179 (35.0)	0.906
Liver disease	42 (6.8)	69 (11.9)	0.003	28 (9.8)	25 (8.7)	0.773	8 (1.6)	12 (2.3)	0.542
Charlson index	9.3 (2.2)	10.5 (2.5)	<0.001	9.8 (2.4)	9.7 (2.3)	0.831	6.5 (1.5)	7.8 (2.7)	<0.001
Complications, n (%)
Sepsis	244 (39.3)	355 (61.1)	<0.001	152 (53.0)	145 (50.5)	0.616	145 (29.2)	272 (53.0)	<0.001
AKI	264 (42.5)	389 (67.0)	<0.001	157 (54.7)	151 (52.6)	0.676	181 (36.5)	238 (46.6)	<0.001
AHF	27 (4.3)	74 (12.7)	<0.001	27 (9.4)	20 (7.0)	0.361	10 (2.0)	16 (3.1)	0.359
ARF	179 (28.8)	259 (44.6)	<0.001	121 (42.4)	105 (36.6)	0.200	191 (38.5)	232 (45.4)	0.031
Vital signs
MAP, mmHg	85.8 (16.9)	81.9 (17.9)	<0.001	84.6 (18.4)	83.8 (17.5)	0.613	86.5 (18.3)	78.9 (18.6)	<0.001
Heart rate, bpm	97.3 (22.2)	97.4 (21.3)	0.915	97.1 (21.8)	97.6 (20.0)	0.782	99.7 (22.0)	101.0 (21.8)	0.339
RR, bpm	21.0 (6.5)	21.3 (6.4)	0.398	20.9 (6.3)	21.3 (6.6)	0.416	21.0 (5.9)	22.3 (6.8)	0.001
SpO2, %	96.0 (3.7)	95.8 (4.2)	0.282	96.1 (3.6)	96.1 (3.6)	0.871	95.1 (7.2)	94.8 (5.7)	0.570
Laboratory results
WBC, × 109/L	11.7 (4.4)	13.6 (4.8)	<0.001	12.6 (4.9)	12.4 (3.8)	0.825	11.5 (4.4)	13.5 (4.1)	0.003
HGB, g/dL	11.0 (2.2)	10.2 (2.1)	<0.001	10.5 (2.1)	10.5 (2.1)	0.795	11.5 (2.3)	10.7 (2.3)	<0.001
PLT, × 109/L	275.8(58.2)	249.9(48.3)	0.001	225.1(74.7)	249.7(75.8)	0.633	257.6 (70.7)	220.0 (60.4)	<0.001
Bilirubin, mmol/L	0.9 (0.3)	1.5 (0.6)	<0.001	12 (0.4)	1.1 (0.3)	0.466	0.8 (0.4)	1.1 (0.5)	0.018
Anion gap, mEq/L	15.0 (3.8)	16.6 (4.9)	<0.001	15.4 (4.2)	16.0 (4.5)	0.142	10.6 (3.5)	11.8 (4.4)	<0.001
Bicarbonate, mEq/L	24.0 (4.6)	22.3 (5.5)	<0.001	23.3 (5.1)	23.0 (4.9)	0.452	26.5 (4.7)	25.0 (5.8)	<0.001
Chloride, mmol/L	100.9 (6.6)	100.9 (7.2)	0.985	101.0 (6.8)	101.1 (6.9)	0.869	99.8 (6.5)	100.6 (6.5)	0.057
Creatinine, mg/dL	0.9 (0.3)	1.6 (0.5)	<0.001	1.0 (0.4)	1.1 (0.4)	0.509	0.8 (0.4)	1.6 (0.5)	<0.001
Potassium, mmol/L	4.1 (0.7)	4.5 (0.8)	<0.001	4.2 (0.7)	4.3 (0.7)	0.414	3.9 (0.5)	4.3 (0.8)	<0.001
Sodium, mmol/L	136.6 (5.4)	136.5 (5.9)	0.756	136.6 (5.5)	136.7 (5.7)	0.829	135.7 (5.7)	136.2 (5.6)	0.131
ICU LOS, days	2.2 (1.2, 3.9)	2.5 (1.5, 5.2)	0.007	2.5 (1.3, 4.2)	2.1 (1.4, 4.5)	0.116	3.0 (2.0, 5.2)	3.2 (2.1, 5.7)	0.403
Hospital LOS, days	9.0 (5.6, 14.7)	9.7 (5.6, 15.4)	0.269	10.0 (6.2, 16.1)	8.9 (5.4, 14.5)	0.003	4.3 (2.9, 7.9)	4.5 (3.1, 8.7)	0.019
Death n(%)	88 (14.2)	225 (38.7)	<0.001	53 (18.5)	85 (29.6)	0.002	71 (14.3)	195 (38.2)	<0.001

Note: For all continuous covariates, the mean values and standard deviations are reported.

Abbreviations: BAR, blood urea nitrogen to serum albumin ratio; MV, mechanical ventilation; CRRT, continuous renal replacement therapy; SOFA, sequential organ failure assessment; OASIS, Oxford acute severity of illness score; APSIII, acute physiology score III; CKD, chronic kidney disease; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; AKI, acute kidney injury; AHF, acute heart failure; ARF, acute respiratory failure; MAP, mean arterial pressure; RR, respiratory rate; WBC, white blood cell; HGB, hemoglobin; PLT, platelet; ICU, intensive care unit; LOS, length of stay.

Prognostic Value of BAR for Primary Endpoint

As described in Table 1, compared with patients in low-BAR group, high-BAR group had a relatively higher in-hospital mortality in original cohort (38.7% versus 14.2%, P<0.001), in matched cohort (29.6% versus 18.5%, P=0.002) as well as in validation cohort (38.2% versus 14.3%, P<0.001). Those findings were further confirmed by Kaplan-Meier curves. As described in Figure2A–C, high BAR group had a poor in-hospital mortality in original cohort, in matched cohort and in validation cohort.

Figure 2.

Kaplan–Meier curves for in-hospital survival for lung cancer patients stratified by BAR in the original cohort (A), in the matched cohort (B), and in the validation cohort (C). Receiver operating characteristic curve analysis of BAR for in-hospital mortality in the original cohort, in the matched cohort, and in the validation cohort (D).

The univariate COX regression analysis indicated that high BAR group patients were associated with increased in-hospital mortality, with a crude hazard ratio (HR) of 2.60 (95% confidence index, 95% CI, 2.03–3.33, P<0.001) and the association remained robust after PSM (HR=2.04, 95% CI 1.44–2.89, P<0.001) and IPTW (HR= 2.00, 95% CI 1.42–2.82, P<0.001) (Table 2). These findings were further confirmed by the results of the multivariate analyses. High BAR was still an independent predictor for in-hospital mortality in original cohort (HR=2.09, 95% CI 1.58–2.76, P<0.001), in matched cohort (OR=2.24, 95% CI 1.57–3.19, P<0.001) and in weighted cohort (OR=2.77, 95% CI 2.03–4.58, P<0.001) after adjustment for age, gender, weight, tumor type, comorbidities, complications, score system, interventions, vital signs and laboratory results (Table 2). Moreover, patients in the validation cohort showed similar results, which indicated that BAR was a significant and robust predictor for in-hospital mortality in lung cancer patients in ICU.

Table 2.

Summary of Results of Primary Outcome

	Original Cohort		Matched Cohort		Weighted Cohort		Validation Cohort
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Unadjusted	2.60 (2.03–3.33)	<0.001	2.04 (1.44–2.89)	<0.001	2.00 (1.42–2.82)	<0.001	2.21 (1.68–2.91)	<0.001
Model 1	2.66 (2.07–3.41)	<0.001	2.10 (1.48–2.99)	<0.001	2.05 (1.44–2.91)	<0.001	2.41 (1.83–3.17)	<0.001
Model 2	2.45 (1.89–3.19)	<0.001	2.13 (1.50–3.03)	<0.001	2.22 (1.54–3.22)	<0.001	2.36 (1.79–3.10)	<0.001
Model 3	2.04 (1.56–2.69)	<0.001	2.28 (1.60–3.25)	<0.001	2.40 (1.63–3.52)	<0.001	2.30 (1.75–3.02)	<0.001
Model 4	2.09 (1.58–2.76)	<0.001	2.24 (1.57–3.19)	<0.001	2.77 (2.03–4.58)	<0.001	2.20 (1.67–2.90)	<0.001

Notes: Model 1 adjusted for age, gender, weight, tumor type. Model 2 adjusted for model 1 plus comorbidities and complications. Model 3 adjusted for model 2 plus score system, interventions and Charlson index. Model 4 adjusted for model 3 plus vital signs and laboratory results.

Abbreviations: HR, hazard ratio; 95% CI, 95% confidence index.

To further investigate whether BAR remained a prognostic factor in certain patient subgroups, we performed exploratory subgroup analyses. Forest plot demonstrated that BAR was an independent prognostic factor in the original cohort in all subgroups (Figure 3A). Moreover, patients from the validation cohort showed similar results. BAR can predict patient survival in almost all subgroups except for patients with acute heart failure and chronic kidney disease (Figure 3B).

Figure 3.

Subgroup analysis for hazard ratio of lung cancer patients with BAR ≥ 6.8mg/g versus BAR < 6.8mg/g in different groups in the original cohort (A) and in the validation cohort (B).

Clinical Usefulness of BAR

BAR exhibited better predictive abilities for in-hospital mortality when compared with BUN or serum albumin alone in the original cohort, in the matched cohort, as well as in the validation cohort (Figure 2D and Table 3).

Table 3.

Receiver Operating Curve Analysis

Variable	Sensitivity	Specificity	AUC (95% CI)	P value
Original cohort
BAR	71.9	60.1	0.720 (0.694–0.745)
BUN	62.9	62.0	0.660 (0.633–0.687)	<0.001
Albumin	51.8	73.6	0.672 (0.646–0.697)	<0.001
Matched cohort
BAR	71.7	50.2	0.673 (0.633–0.711)
BUN	94.2	17.2	0.532 (0.490–0.574)	0.003
Albumin	85.5	35.1	0.613 (0.571–0.653)	0.046
Validation cohort
BAR	68.8	66.4	0.725 (0.697–0.753)
BUN	74.1	50.1	0.649 (0.619–0.679)	<0.001
Albumin	58.3	79.6	0.686 (0.659–0.711)	0.001

Abbreviations: BAR, blood urea nitrogen to serum albumin ratio; BUN, blood urea nitrogen; AUC, area under the receiver operating curve.

A DCA curve was also introduced to evaluate the clinical use of BAR for in-hospital mortality. According to the DCA, when the threshold probability for a patient was within the range of 0–100%, the BAR added more net benefit than the “treat all” or “treat none” strategies both in the original cohort, in the matched cohort, and in the validation cohort, which indicated that BAR could have clinical usefulness (Figure 4A–C).

Figure 4.

Decision curve analysis of BAR for in-hospital mortality in lung cancer patients to detect its clinical usefulness in the original cohort (A), in the matched cohort (B), and in the validation cohort (C).

Discussion

In the current study, we retrospectively enrolled 2209 ICU patients with lung cancer and found that high BAR group patients had increased in-hospital mortality and concluded that initial BAR could be an independent predictor for in-hospital mortality after adjusting confounding factors. In addition, the predictive performance of BAR was superior to that of serum albumin or BUN alone and could add more net benefit in terms of in-hospital mortality rather than “treat all” or “treat none”. Hence, those results suggested that BAR might be a good predictor for identifying patients at high risk of in-hospital mortality among lung cancer patients in ICU.

As one of the leading causes of cancer-related deaths all over the world, lung cancer patients often need invasive monitoring or treatment and have a relatively low survival rate, especially patients in ICU.^9,27 Using the data from surveillance, epidemiology, and end results-medicare registry, Christopher et al demonstrated that the in-hospital mortality was 24% in patients with lung cancer who were admitted to an ICU for reasons other than surgical resection of their tumor.²⁸ In the current study, the in-hospital mortality rate for ICU patients with lung cancer was 26.0% in the original cohort and 26.4% in the validation cohort.

The association between BAR and prognosis in patients with disease of the respiratory system has been investigated in previous studies. Seung et al conducted a retrospective study of 443 patients who were admitted to emergency department and concluded that BAR was a useful prognostic factor of 28-day mortality in aspiration pneumonia patients.²⁹ A similar result has also been found in critically ill patients with acute pulmonary embolism. Using the data extracted from MIMIC-III, Fang et al investigated the correlation between BAR and prognosis of 1048 ICU patients with acute pulmonary embolism and concluded that BAR was an independent predictor for ICU mortality as well as 28-day mortality after ICU admission and the predictive performance of BAR was superior to the SOFA score and APSIII score.³⁰ Moreover, Huang et al conducted a retrospective, observational study of 602 patients and demonstrated that elevated BAR at admission is an independent risk factor for in-hospital mortality in coronavirus disease patients (2019).³¹ Our study added the evidence that BAR was a reliable predictor for prognosis of patients with disease of the respiratory system. We firstly found that initial BAR could be an independent predictor for in-hospital mortality even after adjusting confounding factors in patients with lung cancer who were admitted to ICU. Moreover, the predictive performance of BAR was superior to that of serum albumin or BUN alone and could add more net benefit in terms of in-hospital mortality rather than “treat all” or “treat none”.

A high BAR represents a high BUN concentration and a low albumin level. As a well-known index of renal function, BUN could also reflect the complex mutuality among nutritional status, protein metabolism, and renal condition of the patient.^32,33 Increasing studies have focused attention on the BUN-based index or BUN alone for the prognosis of patients with different types of diseases, such as hemodialysis,³⁴ CKD,³⁵ peripheral arterial disease,³⁶ and so on. Serum albumin plays an important role in immune-modulation, anti-oxidation, anti-inflammatory and endothelial stabilization.^37,38 Moreover, serum albumin levels could be decreased by the status of malnutrition, inflammation, hepatocellular injury, renal losses, and so on.³⁹ Previous studies also demonstrated some albumin-based ratio for the diagnostic and prognostic of lung cancer.^40–42 However, to the best of our knowledge, limited data are available on the combination of BUN and serum albumin for the prognosis of patients with lung cancer considering that the increased BUN and decreased serum albumin levels are in agreement with previous studies. In the current study, we retrospectively enrolled 2209 ICU patients with lung cancer using two large free public databases and noted a positive correlation between BAR and the prognosis of patients. This association became robust even after PSM and IPTW were also employed to eliminate the imbalance of the covariates between high-BAR and low-BAR groups. Furthermore, this association between BAR and in-hospital mortality was further confirmed in another big database with 1007 ICU patients with lung cancer.

Despite the relatively large sample size, there were still some limitations observed in this study. Firstly, we only calculated the initial BAR after their ICU admission but did not assess changes in BAR in any patients during hospital stay. Values of serum albumin or BUN may vary over time, and dynamic monitoring of these values may be more accurate. Secondly, we did not obtain levels of serum C-reactive protein and other inflammatory or nutritional indicators, which may be helpful to investigate the mechanism of the association between BAR and prognosis of lung cancer patients. Finally, this was a retrospective study, further prospective multicenter studies are proposed to validate the conclusions of our study and to investigate the potential mechanism behind them.

Conclusion

In the current study, we firstly demonstrated that initial BAR could serve as an independent prognostic predictor of in-hospital mortality in lung cancer patients in ICU, with good discrimination and clinical usefulness. BAR, which is an easily accessible and cost-effective parameter, provides a helpful index for clinicians to stratify the risk of mortality. Despite the solid statistics of this study, the findings of this study need more validations.

Funding Statement

This study was supported by Wuhan Municipal Health Commission (No: WX21D42).

Data Sharing Statement

All data in our study are available from the corresponding author upon reasonable request.

Statement of Ethics

This study was conducted in accordance with the Helsinki Declaration and authors had successfully accomplished the National Institutes of Health’s (NIH) online training course and the Protection of Human Research Participants Examination and got the permission to extract data from MIMIC IV and eICU databases. Moreover, the study protocol was reviewed and successfully approved by the Ethics Committee of the Second Affiliated Hospital of Jianghan University and informed consent was waived.

Disclosure

The authors declare that they have no competing interests.