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. 2021 Oct 2;24(10):103208. doi: 10.1016/j.isci.2021.103208

Figure 1.

Figure 1

Computational model of miR-125b-modulated portion of the apoptosis pathway

(A) Diagram of the modeled portion of the apoptosis pathway. Blue and orange boxes represent pro-apoptotic and anti-apoptotic members of the pathway that are targeted by miR-125b, respectively. Green boxes represent closely interacting members of the pathway that are not targeted by miR-125b. Green arrowheads from P53 represent transcriptional activation. Gold arrowheads represent activation of inactivated BAX/BAK1 (inBAX/inBAK1) to the form of activated BAX/BAK1 (aBAX/aBAK1). Hammerheads represent inhibition by competitive binding. Activated BAX and BAK1 form homodimers on the mitochondrial membrane, which are in turn linked together to form pores that result in increased mitochondrial outer membrane permeability (MOMP) and apoptosis.

(B) Model-predicted MOMP as a function of time for varying degrees of fractional inhibition of miR-125b′s targets in the apoptosis pathway.

(C) Steady State MOMP as a function of the relative inhibition of miR-125b′s targets in the apoptosis pathway. For (B) and (C), the model was run with the default parameter values and 400 nM baseline activator.