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. 2021 Sep 23;40(44):6235–6247. doi: 10.1038/s41388-021-02017-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Correlation analysis of ISG15 and UBE2L6 mRNA expression levels in breast cancer samples. The spearman’s correlation is 0.66, p value < 2.2e-16 B Boxplots showing the correlation between an Akt-activity gene-signature and ISG15 mRNA in in lymph node negative basal breast cancer (n = 68), luminal A (n = 174), and luminal B (n = 41). p values are displayed below each graph. C Boxplots showing the correlation between an Akt-activity gene-signature and ISG15 mRNA in in lymph positive basal breast cancer (n = 36), luminal A (n = 188) and luminal B (n = 53). p values are displayed below each graph. D Correlation between pAkt and ISG15 mRNA levels in tumours without lymph node metastasis as a whole (n = 166) or classified by subtype; luminal A (n = 62), luminal B (n = 17), basal (n = 28) and HER2 (n = 6). E Correlation as in D in tumours positive for lymph node metastasis as a whole (n = 156) or classified by subtype: Luminal A (n = 65), Luminal B (n = 18), Basal (n = 13) and HER2 + (n = 9). F As B for UBE2L6 mRNA expression. In red boxes, tumour subtypes that showed a statistically significant correlation between pAkt and ISG15 or UBE2L6 mRNA.