Abstract
Oral cavity squamous cell carcinoma (OSCC) is a leading cause of death in Taiwan. Most of the patients in the literature are male. The risk factors, cancer characteristics, and treatment outcomes were investigated in female patients and compared with male patients in this study.
This retrospective study recruited 2046 OSCC patients between 1995 and 2019. The age, tumor subsites, and survival were reviewed and recorded. Overall survival and disease-free survival were the main outcomes.
Female patients represented 6.7% of the entire study cohort. Females were diagnosed at an older age and an earlier local stage than male patients (P < .001). Female patients were less exposed to cigarettes, alcohol, and betel-quid (all P < .001). The tongue (55.1%) was the most frequent subsite in females, while the buccal cavity (38.4%) and the tongue (35.3%) were more likely (P < .001) to be associated with the male gender. Female patients in the tongue cancer subgroup presented less frequently with extra-nodal extension compared with male patients (P = .040). No significant differences in recurrence or overall deaths were observed between the genders during the follow-up period.
The OSCC male to female ratio in Taiwan was 14:1. Female OSCC occurred more frequently on the tongue, and was diagnosed at an older age and at an earlier tumor stage than in male patients. No survival difference was found between female and male OSCC patients.
Keywords: female, gender, male, oral cavity cancer, survival
1. Introduction
1.1. Background
Oral cavity squamous cell carcinoma (OSCC) is the sixth most prevalent cancer worldwide and is a leading cause of death in Taiwan, particularly in the male population.[1] OSCC is in the top five causes of death according to the Ministry of Health and Welfare of Taiwan.[2] The incidence is about 7000 cases annually in Taiwan, which led to 3027 deaths in 2018. Among the deaths, 2779 were males, accounting for 90% of the mortality caused by OSCC.[2] OSCC globally affects males more frequently than females, and the ratio is highest in Taiwan (male to female ratio: 10.5).[3] The consumption of cigarettes, alcohol, and betel quid (BQ) predisposes male Taiwanese patients to develop OSCC. It is estimated that cigarettes and alcohol contribute to about 80% of OSCC cases.[1] In Taiwan, the significant sex-related differences in the frequency of tobacco and BQ chewing may explain the higher incidence of OSCC in males (20.81 cases per 1 million persons) than in females (2.40 cases per 1 million persons).[4]
Due to the substantially lower number of female patients with OSCC, most studies have focused on the male population. Therefore, little is known about differences in risk factors contributing to oral cancer and the treatment outcomes in women. Female patients are exposed to fewer environmental carcinogens in BQ endemic regions, such as Taiwan and India. Some studies have indicated that OSCC may exhibit different risk factors between the genders.[5,6] Nevertheless, one study conducted in Italy and Switzerland showed that tobacco smoking and alcohol consumption represent significant risk factors for women and men. Furthermore, Honorato et al reported no significant difference in the survival rate between the genders.[7,8]
1.2. Objectives
This study aimed to investigate differences in characteristics, risk factors, and treatment outcomes between female and male patients affected with OSCC in Taiwan.
2. Methods
2.1. Study design
This was a retrospective cohort study.
2.2. Setting
Tertiary referral medical center.
2.3. Participants (cohort study)
We retrospectively collected data from a single medical center (Chang Gung Memorial Hospital, Linkou branch, Taiwan). The data consisted of 2046 participants diagnosed with OSCC (involving the tongue, buccal cavity, hard palate, gingiva, and floor of the mouth) between July 1995 and March 2019. All data were collected in compliance with the Declaration of Helsinki. This study was approved by the Institutional Review Board of Chang Gung Memorial Hospital [IRB no: 202000599B0]. All patients received preoperative magnetic resonance imaging, chest X-rays, liver sonography, and bone scan/positron emission tomography. All patients underwent radical surgery as their first treatment.
2.4. Inclusion and exclusion criteria
The inclusion criteria were patients with histologically proven OSCC and those who underwent radical surgery as the first treatment. Patients who had been diagnosed with verrucous carcinoma or a salivary gland malignancy were excluded. Those who had distant metastasis at the time of the diagnosis were also excluded from the analysis.
2.5. Variables
Clinical data were collected from the medical records. The staging system was based on the American Joint Committee on Cancer TNM staging system (AJCC, 2010 edition).[9] After the radical surgery, tumors with adverse pathological factors, such as advanced tumor stage (T3 or T4), poor tumor differentiation, lymph node extra nodal spread (ENE), or tumor depth ≥10 mm underwent adjuvant radiotherapy or chemo-radiotherapy.[10,11] Patients were included if they had complete information and patients with distant metastasis or recurring OSCC were excluded.
2.6. Bias
All data were collected in as much detail as possible. We minimized the missing data as much as possible.
2.7. Study size
A total of 2046 participants diagnosed with OSCC were recruited over 14 years.
2.8. Data measurement
Tobacco, alcohol, and BQ consumption history were divided into never used and ever/current user groups. The cancer sites included the tongue, the mouth floor, the lips, the buccal cavity, the alveolus (gums), the hard palate, and the retromolar trigone. The pathological parameters included tumor size, tumor depth, perineural invasion, and lymph node metastasis. Lymph node status was further classified into negative and positive lymph node metastasis without ENE and positive lymph node metastasis with ENE. Tumor size was classified as “small” if the patient had a T1/T2 tumor and “large” for a T3/T4 tumor. Cancer stages I and II were classified as early cancer, and stage III/IV was classified as “advanced”. All patients were regularly followed up after the surgery. They returned to the clinic every month during the first year, every 2 months during the second year, every 3 months during the third year, every 4 months during the fourth year, and every 6 months after 5 years.
2.9. Statistical methods
The age, tumor subsite, cigarette smoking, BQ chewing, and alcohol drinking distributions of all OSCC patients were calculated. Statistical analysis was utilized to compare variables, such as age, tumor subsites, and lymph node metastasis between males and females. To assess the differences, the chi-square test was used for categorical variables and the t-test was used for continuous variables. All P-values <.05 were considered significant. Multivariate analysis was conducted using Cox regression. The curves of age at disease onset between the genders were compared using the Kolmogorov-Smirnov test. Overall survival (OS) and disease-free survival (DFS) were assessed using the Kaplan-Meier method, and the differences were estimated with the log-rank test. All analyses were conducted using STATA version 15 software (StataCorp Llc, College Station, TX).
3. Results
3.1. Participants
Age, tumor subsite, and habitual exposure distributions are listed in Table 1. A total of 2046 patients met the inclusion criteria and were included for further analysis. The study population consisted of 1910 males (93.4%) and 136 females (6.6%).
Table 1.
Demographic data, environmental exposure, and tumor stage distribution of all OSCC patients (n = 2046).
| N (%) | S.D. | ||
| Gender | Male | 1910 (93.4) | |
| Female | 136 (6.7) | ||
| Age | 50.7 | 11.2 | |
| Smoking | Never | 313 (15.3) | |
| Yes | 1733 (84.7) | ||
| Alcohol | Never | 570 (27.9) | |
| Yes | 1476 (72.1) | ||
| Betel-quid | Never | 411 (20.1) | |
| Yes | 1635 (79.9) | ||
| Cancer site | Tongue | 723 (35.3) | |
| Mouth floor | 72 (3.5) | ||
| Lip | 70 (3.4) | ||
| Buccal | 786 (38.4) | ||
| Gum | 237 (11.6) | ||
| Hard palate | 49 (2.4) | ||
| Retromolar | 109 (5.3) | ||
| Nodal stage | N– ECS– | 1273 (62.2) | |
| N+ ECS– | 313 (15.3) | ||
| N+ ECS+ | 460 (22.5) | ||
| Tumor stage | T1/T2 | 1228 (60.0) | |
| T3/T4 | 818 (40.0) | ||
| Overall stage | Early | 857 (41.9) | |
| Advanced | 1189 (58.1) | ||
| Recurrence | Yes | 649 (31.7) | |
| No | 1397 (68.3) |
3.2. Descriptive data
The male-to-female ratio was 14:1 in this study. The average age of the participants was 50.7 years (standard deviation [SD]: 11.2, range: 24.0–92.0.) Most of the participants had a history of smoking (84.7%), alcohol use (72.1%), and BQ chewing (79.9%). Cancer sites were more frequently detected on the tongue (35.3%) and buccal mucosa (38.4%). More than half of the participants (58.1%) were diagnosed at an advanced stage. During the follow-up period, 649 (31.7%) participants developed a recurrence.
Table 2 shows a comparison of the characteristics between the genders. Male patients were diagnosed with OSCC at a younger age (mean ± SD: 50.2 ± 10.90 years) compared to female patients (mean ± SD: 57.1 ± 13.11 years, P < .001, Fig. 1). The consumption of cigarettes, alcohol, and BQ varied between the genders. The majority of male patients had a history of consuming cigarettes, alcohol, and BQ, whereas the female patients did not (Table 2, all P < .001).
Table 2.
Comparison of patient characteristics between male and female OSCC patients (N = 2046).
| All OSCC patients | Tongue cancer patients | ||||||
| Male [n (%)] | Female [n (%)] | P-value | Male [n (%)) | Female [n (%)) | P-value | ||
| 1910 (93.4) | 136 (6.7) | 648 (89.6) | 75 (10.4) | ||||
| Age | 50.2 (49.7–50.7) | 57.1 (54.9–59.4) | <.001 | 48.4 (28.0–49.6) | 53.6 (50.6–56.6) | <.001 | |
| Smoking | Never | 214 (11.2) | 99 (72.8) | <.001 | 86 (13.3) | 57 (76.0) | <.001 |
| Yes | 1696 (88.8) | 37 (27.2) | 562 (86.7) | 18 (24.0) | |||
| Alcohol | Never | 464 (24.3) | 106 (77.9) | <.001 | 158 (24.4) | 59 (78.7) | <.001 |
| Yes | 1446 (75.7) | 30 (22.1) | 490 (75.6) | 16 (21.3) | |||
| Betel-quid | Never | 313 (16.4) | 98 (72.1) | <.001 | 118 (18.2) | 60 (80.0) | <.001 |
| Yes | 1597 (83.6) | 38 (27.9) | 530 (81.8) | 15 (20.0) | |||
| Cancer site | Tongue | 648 (33.9) | 75 (55.1) | <.001 | |||
| Mouth floor | 68 (3.6) | 4 (2.9) | |||||
| Lip | 64 (3.1) | 6 (4.4) | |||||
| Buccal | 760 (39.8) | 26 (19.1) | |||||
| Gum | 219 (11.5) | 18 (13.2) | |||||
| Hard palate | 46 (2.4) | 3 (2.2) | |||||
| Retromolar | 105 (5.5) | 4 (0.2) | |||||
| Nodal stage | N- ENE- | 1190 (62.3) | 83 (61.0) | .557 | 390 (60.2) | 48 (64.0) | .040 |
| N+ ENE - | 288 (15.1) | 25 (18.4) | 97 (15.0) | 17 (22.7) | |||
| N+ ENE + | 432 (22.6) | 28 (20.6) | 161 (24.9) | 10 (13.3) | |||
| Tumor stage | T1/T2 | 1127 (59.0) | 101 (74.3) | <.001 | 476 (73.5) | 70 (93.3) | <.001 |
| T3/T4 | 783 (41.0) | 35 (25.7) | 172 (26.5) | 5 (6.7) | |||
| Overall stage | Early | 793 (41.5) | 64 (47.1) | .206 | 325 (50.2) | 46 (61.3) | .067 |
| Advanced | 1117 (58.5) | 72 (52.9) | 323 (49.9) | 29 (38.7) | |||
| Recurrence | Yes | 613 (32.1) | 36 (26.5) | .173 | 454 (70.1) | 55 (73.3) | .557 |
| No | 1297 (67.9) | 100 (73.5) | 194 (29.9) | 20 (26.7) | |||
Figure 1.
(A) The cumulative case number percentage according to the age of the OSCC patients (P < .001, by Kolmogorov-Smirnov test). (B) The cumulative case number percentage according to the age of the tongue cancer patients (P = .05 by Kolmogorov-Smirnov test).
3.3. Outcome data
The cancer sites also varied significantly between the genders (P < .001). The most common cancer site in male patients was the buccal cavity (39.8%) followed by the tongue (33.9%). Unlike male patients, more than half of the female patients were diagnosed with tongue cancer (55.1%), followed by buccal cancer (19.1%). The overall stage of the diagnosed disease was similar between the genders: 41.5% were early-stage in males and 47.1% were early-stage in females (P = .206). During the follow-up period, about one-third (32.1%) of male patients developed a recurrence, whereas one-quarter (26.5%) of female patients developed a recurrence (P = .17).
3.4. Main results
We further analyzed the patients with tongue cancer, as the tongue was the most commonly affected site in male (33.9%) and female patients (55.1%). The disease characteristics and treatment outcomes were compared between the genders. Table 2 shows a comparison between the genders in the patients with tongue cancer. The females accounted for about 10% of tongue cancer cases, which was similar to the gender distribution of all OSCC patients. Females were about 5 years (53.6, 95% confidence interval [CI]: 50.6–56.6) older when diagnosed with tongue cancer than males (48.4, 95% CI: 28.0–49.6) (Fig. 1, P = .05). As in all OSCC patients, most males were heavy tobacco, alcohol, and BQ users, whereas females were not. More females (93.3%) with tongue cancer were diagnosed at an early tumor status, which was significantly different compared to 73.5% of males diagnosed at an early stage (P < .001). The proportion of tongue cancer patients without lymph node involvement was similar between the genders. However, the females had less ENE if they had lymph node involvement compared with males (N+ENE+, females: 13.3%; males: 24.9%, P = .040). The difference in the overall stage between the genders was not significant (P = .07).
Table 3 summarizes the results of the multivariate analysis in all OSCC and tongue cancer patients. In the OSCC patients, advanced tumor stage and lymph node involvement with or without ENE were independent risk factors for survival or recurrence. ENE was a strong risk factor for death and recurrence (DFS: hazard ratio [HR] 2.04 (95% CI: 1.69–2.45, P < .001); OS: HR 2.78 (95% CI: 2.31–3.33, P < .001)). After adjustment, patients >50 years had a higher HR for death than those <50 years (95% CI: 1.10–1.52, P < .001). In tongue cancer patients, lymph node involvement with or without ENE was an independent risk factor for recurrence and survival, particularly in the ENE group (DFS: HR 2.16 (95% CI: 1.56–3.00, P < .001); OS: HR 3.61 (95% CI: 2.60–5.03, P < .001)). The tumor stage only played a role in the survival of tongue cancer patients; patients with an advanced tumor stage had a higher HR for death (95% CI: 1.09–2.05, P = .012). After adjustment, sex and age were not significantly associated with death or recurrence.
Table 3.
Multivariate analysis of variables influencing patient survival.
| DFS(All subsites) (n = 1979) | OS(All subsites) (n = 1979) | DFS(Tongue cancer) (n = 710) | OS(Tongue cancer) (n = 710) | ||||||
| Variables | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Sex | Male | 1 | .49 | 1 | .38 | 1 | .57 | 1 | .12 |
| Female | 0.86 (0.63–1.25) | 0.86 (0.61–1.21) | 0.87 (0.54–1.40) | 0.64 (0.36–1.13) | |||||
| Age | <50 y | 1 | .095 | 1 | .001 | 1 | .25 | 1 | .27 |
| ≥50 y | 0.87 (0.74–1.02) | 1.30 (1.10–1.52) | 0.84 (0.63–1.13) | 1.18 (0.88–1.58) | |||||
| T stage | Early | 1 | <.001 | 1 | <.001 | 1 | .10 | 1 | .012 |
| Advanced | 1.50 (1.28–1.77) | 1.83 (1.55–2.15) | 1.31 (0.95–1.79) | 1.50 (1.09–2.05) | |||||
| N stage | N- ENE- | 1 | 1 | 1 | 1 | ||||
| N+ ENE- | 1.40 (1.12–1.76) | .003 | 1.92 (1.54–2.39) | <.001 | 1.62 (1.11–2.36) | .012 | 2.23 (1.50–3.32) | <.001 | |
| N+ ENE+ | 2.04 (1.69–2.45) | <.001 | 2.78 (2.31–3.33) | <.001 | 2.16 (1.56–3.00) | <.001 | 3.61 (2.60–5.03) | <.001 | |
3.5. DFS and OS
A total of 1979 patients with complete information at the time of diagnosis and death, and 509 deaths among them, were related to OSCC. In total, 480 (7.7%) males and 29 (7.5%) females died during the follow-up. In contrast, 624 patients developed a recurrence. Half of the recurrences occurred within 8.79 years after treatment. Of the patients who developed a recurrence, 589 were male and 35 were female. The frequencies of recurrence among the female and male populations were 9.4% and 10.5%, respectively. Figure 2A shows the DFS curves and Figure 2B shows the Kaplan-Meier OS curves between the genders. There was weak evidence of a difference in OS between females and males during the follow-up period (log-rank test: P = .491). No difference in DFS was observed between the genders (log-rank test: P = .280). DFS was not different between females and males with tongue cancer (P = .336) (Fig. 3A). However, OS in females with tongue cancer tended to be better than males (5-year OS: 91.6% vs. 87.1%, P = .074) (Fig. 3B).
Figure 2.
(A) Kaplan-Meier disease-free survival curve between the genders (log rank test: P = .280). (B) Kaplan-Meier overall survival curve between the genders (log rank test: P = .491).
Figure 3.
(A) Disease free survival in tongue cancer patients of both genders (log rank test: 0.336). (B) Overall survival in tongue cancer patients of both genders (log rank test: 0.074).
4. Discussion
4.1. Generalizability
This study included 2046 patients from a single medical center. However, it overlapped different staging systems (6th, 7th, and 8th AJCC editions). We adopted the 7th edition throughout this study. In this study, more than 90% of the participants were male. Males were more likely to be diagnosed with OSCC at a younger age and with late tumor status compared to female patients. This age difference can be explained in two ways. First, patients in BQ endemic areas develop OSCC at a younger age, compared to other populations not exposed to this risk factor.[1,12] Second, female patients were rarely exposed to cigarettes, alcohol, or BQ, unlike the male patients; therefore, other factors, such as poor oral hygiene, inadequate dental status, and chronic irritation, which represent independent risk factors for OSCC, regardless of tobacco and alcohol use, may have played a role in carcinogenesis.[13] Patients who do not smoke or drink alcohol tend to present at extreme ages.[14] It is reasonable to say that the female population, with less carcinogen exposure, developed BQ later in their lives.
4.2. Key results
The tongue (55.1%) was the most frequent anatomical site of OSCC in female patients. This finding correlates well with the literature. Several studies have reported higher involvement at this subsite, particularly in nonsmoking and nondrinking women with human papillomavirus (HPV)-negative OSCC.[15] In contrast, we noticed a slightly higher median age of our cohort, compared to another study.[16] We interpreted this discrepancy as a result of differences in epidemiology. Most studies have been conducted in western countries and low OSCC prevalent areas. Lin et al[17] investigated the clinicopathological features in the Taiwanese population affected by OSCC and obtained similar results regarding the age of female patients. Furthermore, Foy et al reported a possible relationship between the development of OSCC in nonsmoking, nondrinking French patients, and viral infection. They hypothesized that changes in sexual behaviors in western countries may lead to an increased incidence of the herpes virus in the oral cavity, particularly HSV-2, which is similar to what has already been described for HPV-positive OSCC. Because viral genome integration has not been detected in nonsmoking and nondrinking patients with OSCC, a “hit and run” viral mechanism involving epigenome deregulation could play a key role during the early stages of oral carcinogenesis in this population of patients.[18] In our cohort, males were more likely to develop buccal (38.4%) and tongue (35.3%) OSCC. The buccal mucosa is the most affected site in people with a BQ chewing history due to frequent irritation of the mucosa. As most of the male patients (79.9%) in our study had a BQ chewing history, buccal cancer was more likely to be found in male participants. The tumor stage at diagnosis differed between the genders. Most (74.3%) of the females had early tumor stages at the time of the OSCC diagnosis, whereas only about 60% of male patients had an early tumor stage. However, lymph node status and the overall stage did not vary between the genders. When we performed further analysis on patients with tongue cancer, female patients were diagnosed at an older age and with smaller tumor sizes. Females had less ENE if they had lymph node involvement compared to males (N+ENE+, males: 24.9%; females: 13.3%). In nonsmoking and nondrinking patients with OSCC, the frequency of lymph node metastasis and ENE was less than the smoking and drinking group. The patients who smoked cigarettes and drank alcohol tended to have a higher risk of lymph node ENE,[19] which could be related to the tumorigenesis mechanism. Oral cancers related to smoking and BQ could harbor more genetic changes from environmental carcinogen exposure and could metastasize more easily, or develop ENE. The other possibility is that tongue cancers in males are at a more advanced stage. The accumulated mutations with the tumor stage make tumor cells aggressive and easier to metastasize.
4.3. Interpretation
There was no evidence of a difference in recurrence or death between the genders during the follow-up period. As OSCC was most prevalent in the male population, most of the literature has investigated the characteristics, risk factors, treatments, and outcomes of OSCC in the male population. Few studies have investigated this disease in females. We reviewed the studies about OSCC between the genders. Honorato et al[8] compared the prognostic differences in OSCC between genders in Brazil. The data showed similar alcohol and cigarette habits between the genders, as in our population, whereas the anatomical sites of cancer differed from our results, which was due to the lack of BQ use. The tongue was the most affected site in males and females.[8] Due to the BQ consumption culture in Taiwan, the buccal cavity is the most affected site in OSCC patients in Taiwan, unlike the results for Brazil. A European study presented the risk factors of oral and pharyngeal cancer in women in Italy and Switzerland.[7] That study showed that women share the same major risk factors, such as the use of cigarettes and alcohol, as men.
The rate of HPV infection in OSCC is 13.4%, while the infection rate is 36.7% in patients with oropharyngeal cancer in the United States.[20] The HPV infection rate in OSCC is lower than that in oropharyngeal cancer. The frequency of HPV infection (9.6%) was much lower in female OSCC patients than in males (15.8%). In this large cohort study, female OSCC patients had better OS regardless of HPV status, which is why we speculated that the survival rates in our study would not be significantly affected, as HPV status was not determined in our analysis.
4.4. Limitations
Some limitations of our retrospective study should be discussed. Only 136 patients were female among the 2046 participants in our study. However, this is one of the largest studies recruiting female OSCC patients who underwent surgery as the primary treatment. HPV-related head and neck cancers have been increasing in recent years, particularly in the younger population, and in those not exposed to tobacco or alcohol. This study provides epidemiological data on female OSCC in a BQ endemic area. Furthermore, cohort studies at different periods are required to compare the trends in female OSCC.
5. Conclusions
In this study, we demonstrated that the male to female ratio of OSCC in Taiwan was 14:1. Cigarettes, alcohol, and BQ were significantly less frequently used by female patients. Female OSCC occurred more frequently on the tongue, was diagnosed at an older age (7 years older than male OSCC), and was at an earlier tumor stage than those in male patients. No differences in DFS or OS were found between female and male OSCC patients.
Acknowledgments
The authors thank all members of the Cancer Center, Chang Gung Memorial Hospital, Linkou, Taiwan, for their invaluable help.
Author contributions
Conceptualization: Yi-Chieh Lee, Shiang-Fu Huang.
Data curation: Yi-Chieh Lee, Chi-Kuang Young, Huei-Tzu Chien, Shy-Chyi Chin, Andrea Landelli, Chun-Ta Liao, Chung-Kang Tsao, Chung-Jan Kang, Shiang-Fu Huang.
Formal analysis: Yi-Chieh Lee, Chi-Kuang Young, Shiang-Fu Huang.
Funding acquisition: Shiang-Fu Huang.
Investigation: Chi-Kuang Young, Huei-Tzu Chien, Shy-Chyi Chin, Andrea Landelli, Chun-Ta Liao.
Methodology: Chi-Kuang Young, Huei-Tzu Chien, Chung-Jan Kang.
Software: Yi-Chieh Lee, Chi-Kuang Young, Huei-Tzu Chien.
Supervision: Chun-Ta Liao, Chung-Kang Tsao, Shiang-Fu Huang.
Validation: Shy-Chyi Chin, Andrea Landelli, Chun-Ta Liao, Chung-Kang Tsao.
Visualization: Huei-Tzu Chien.
Writing – original draft: Yi-Chieh Lee, Shiang-Fu Huang.
Writing – review & editing: Chi-Kuang Young, Huei-Tzu Chien, Shy-Chyi Chin, Andrea Landelli, Chun-Ta Liao, Chung-Kang Tsao, Chung-Jan Kang, Shiang-Fu Huang.
Correction
When originally published, Dr. Andrea Iandelli's lastname was spelled incorrectly as Landelli. this has been corrected.
Footnotes
ENE = extra-nodal extension.
The values in bold stand for P value <0.05.
DFS = disease-free survival, ENE = extra-nodal extension, HR = hazard ratio, OS = overall survival.
The values in bold stand for P value <0.05.
S.D. = standard deviation.
Abbreviations: BQ = betel-quid, DFS = disease-free survival, ENE = extranodal spread, HPV = human papilloma virus, HR = hazard ratio, OS = overall survival, OSCC = oral cavity squamous cell carcinoma, PET = positron emission tomography.
How to cite this article: Lee YC, Young CK, Chien HT, Chin SC, Iandelli A, Liao CT, Tsao CK, Kang CJ, Huang SF. Characteristics and outcome differences in male and female oral cavity cancer patients in Taiwan. Medicine. 2021;100:44(e27674).
This manuscript was previously posted to bioRxiv: doi: https://doi.org/10.21203/rs.3.rs-53503/v1.
The English in this document has been checked by at least two professional editors, both native speakers of English. For a certificate, please see: http://www.textcheck.com/certificate/rGeMoF
This study was supported by grants (CMRPG3L0861, CMRPG3J0593, and CMRPB53) from Chang Gung Memorial Hospital and a grants (MOST106-2314-B-182-025-MY3, MOST 109-2314-B-182-015 and MOST 110-2314-B-182 -045 -MY3) from the Ministry of Science and Technology, Executive Yuan, Taiwan, ROC, and by the Health and Welfare Surcharge on Tobacco Products (grant MOHW109-TDU-B-212-134016) from the Ministry of Health and Welfare (MOHW), Executive Yuan, Taiwan, ROC.
The authors have no conflicts of interest to disclose.
The datasets generated during and/or analyzed during the current study are not publicly available, but are available from the corresponding author on reasonable request.
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