Table 6.

Interaction between log₁₀endotoxin and GRS in relation to FEV₁/FVC

Exposure	n	FEV1/FVC
		Intercept*	log10endotoxin effect†	GRS effect‡	GRS×log10endotoxin interaction§	Pinteraction¶
Endotoxin
log10endotoxin	2208	0.754	−0.004	−0.004	−0.001	0.248

*The intercept is the FEV₁/FVC value for a subject calculated at the mean value for all continuous variables in the model (GRS, log₁₀endotoxin, age, age², height, height², pack-years and 10 principal components) and at the reference category for all categorical covariates (ie, never smoker, non-asthmatic, summer season of collection, female and residing at Iowa).

†The effect of log₁₀endotoxin is the difference in FEV₁/FVC per unit increase in log₁₀endotoxin, calculated at the mean value for all continuous variables (GRS, age, age², height, height², pack-years and 10 principal components) and at the reference category for all categorical covariates (ie, never smoker, non-asthmatic, summer season of collection, female and residing at Iowa).

‡The effect for the GRS is the slope for the GRS, which is interpretable as the difference in FEV₁/FVC per unit increase in the GRS, calculated at the mean value for all continuous variables (log₁₀endotoxin, age, age², height, height², pack-years and 10 principal components) and at the reference category for all categorical covariates (ie, never smoker, non-asthmatic, summer season of collection, female and residing at Iowa).

§The interaction effect between the GRS and log₁₀endotoxin is the difference in the effect estimate for the GRS per unit increase in log₁₀endotoxin.

¶The p value for interaction between the GRS and log₁₀endotoxin.

GRS, Genetic Risk Score.