Table 1–

Selected Baseline Characteristics of Overall SPRINT cohort and the CKD and non-CKD subgroups^{3, 9–10}

Characteristic	Overall Cohort (N – 9361)	CKD (N - 2646)	Non-CKD (N – 6715)
Age, y, mean ± SD	67.9 ± 9.4	71.9 ± 9.3	66.3 ± 9.0
- Age ≥ 75yr, %	28.2	43.9	21.9
Women, %	35.6	40.0	33.7
Race, %
- non-Hispanic White	57.7	67.2	54.0
- Black Race	29.9	24.1	32.2
- Hispanic Race	10.5	7.2	11.8
- Other	1.9	1.6	2.0
Clinical Cardiovascular Disease*, %	16.7	19.7	14.0
Never Smoked, %	44	45.6	43.5
Serum Creatinine, mg/dL, mean ± SD	1.07 ± 0.34	1.43 ± 0.39	0.93 ± 0.17
eGFR, ml/min per 1.73m2, mean ± SD	71.8 ± 20.6	47.9 ± 9.5	81.2 ± 15.5
- eGFR 45 – 59, %	18.8	66.0	n/a
- eGFR < 45, %	9.5	34.0	n/a
Urinary ACR, mg/g
- mean (SD)	42.6 ± 166.3	80.6 ± 243.4
- median (IQR)		13.3 (6.4 – 43.1)	8.6 (5.5 – 17.1)
BP, mm Hg, mean ± SD
- Systolic	139.7 ± 15.6	139.2 ± 16.1	139.9 ± 15.4
- Diastolic	78.1 ± 11.9	74.9 ± 12.2	79.4 ± 11.6
No. of antihypertensives agents, mean ± SD	1.8 ± 1.0	2.1 ± 1.0	1.7 ± 1.0

^*Clinical CV Disease:

- Previous MI, percutaneous coronary intervention, coronary artery bypass, carotid endarterectomy, carotid stenting.

- Peripheral arterial disease with revascularization.

- Acute coronary syndrome with or without resting ECG changes, ECG changes on a graded exercise test, or positive cardiac imaging study.

- ≥ 50% diameter stenosis of a coronary, carotid, or lower extremity artery.

- Abdominal aortic aneurysm (AAA) ≥ 5cm with or without repair.

CKD – chronic kidney disease, SD – standard deviation, eGFR – estimated glomerular filtration rate, ACR – albumin to creatinine ratio, BP – blood pressure.