Table 1.
Summary of the effects of ICV dosing of the intact GIP and acyl-GIP on body weight and food intake
| Peptides | Dose (pmol) | Duration | Species | Diet | Effect on body weight | Effect on food intake | First author (reference no.) |
|---|---|---|---|---|---|---|---|
| GIP | 20 | 30 min | Rat | NC | — | No | Woods (25) |
| GIP | 20/day | 4 days | Rat | NC | No | No | Ambati (26) |
| GIP | 200/day | 4 days | Rat | NC | No | No | |
| GIP | 2,000/day | 4 days | Rat | NC | Decrease | No | |
| GIP | 1,000 | 0–24 h | Mouse | NC | No | No | NamKoong (27) |
| GIP | 3,000 | 0–24 h | Mouse | NC | No | No | |
| GIP | 6,000 | 0–24 h | Mouse | NC | No | Decrease | |
| GIP | 30 | 24 h | Mouse | NC | — | No | Kaneko (13) |
| GIP | 3,000 | 24 h | Mouse | NC | No | No | Fu (49) |
| GIP | 30/day | 0–3 days | Mouse | NC | No | No | |
| GIP | 3,000/day | 0–3 days | Mouse | NC | No | No | |
| Acyl-GIP | 1,000 | 0 to ∼90 h | Mouse | HFD | Decrease | Decrease | Zhang (29) |
| Acyl-GIP | 3,000 | 0 to ∼90 h | Mouse | HFD | Decrease | Decrease | |
| Acyl-GIP | 6,000 | 0 to ∼90 h | Mouse | HFD | Decrease | Decrease | |
| Acyl-GIP | 20/day | 0–12 days | Mouse | HFD | Decrease | Decrease | |
| Acyl-GIP | 40/day | 0–12 days | Mouse | HFD | Decrease | Decrease |
NC, normal chow diet.