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. 2021 Jun 2;70(9):2067–2080. doi: 10.2337/db20-1177

Figure 2.

Figure 2

Maintenance of the IBF is associated with a strong increase in tolerogenic DCs. Open circles and filled circles are representative of mice fed a CCD or an HFD, respectively, for 24 weeks. A: Kinetics of plasma levels of dextran-FITC (FD 4 kDa) (600 mg/kg body wt) (N = 10–14 mice/subcutaneous group). FD4 plasma levels 3 h after oral gavage (B) and Lcn-2 (C) and sIgA (D) levels in the feces determined by ELISA. E: Mean proportions of CD103+CD11b+, CD103+CD11b−, and CD103− among totDCs in the SILP and the CLP. Proportions (F) and total numbers (nb) (G) of CD103+CD11b+ DCs in the SILP. Proportions (H) and total numbers (I) of CD103+CD11b+ DCs in the CLP. Percentage (J) and total numbers (K) of totDCs among CD45+ cells in the mLNs. Percentage (L) and total numbers (M) of CD103+CD11b+ DCs in the mLNs. Data are presented as mean for circle graphs, median for dot plots, and mean ± SD for others. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.