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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Cytokine. 2021 Jul 19;146:155641. doi: 10.1016/j.cyto.2021.155641

Figure 2: Signaling cascade downstream of IL-17C.

Figure 2:

IL-17C activates the transcription factors NF-κB (RelA and p50) and AP-1. Phosphorylation of ERK, p38, and JNK has been demonstrated in colon epithelial cells. List of antimicrobial agents, cytokines, and chemokines are highlighted in Table 2. Solid arrows represent activation pathways, whereas dashed arrows represent translocation through the nuclear membrane. Image created using BioRender.com