An 89-year-old woman presented at an emergency outpatient service owing to bleeding from the umbilicus induced by abrasion. She had an umbilical hernia with a recent history of occasional bleeding. However, the bleeding stopped spontaneously, and no specific treatment was administered. The patient had an oval-shaped protruding umbilicus (major axis=45 mm; minor axis=25 mm) with a purple lesion caused by abrasion and palpable plate-like nodules in the subcutaneous area (Picture 1). The bleeding stopped with pressure, but computed tomography confirmed end-stage pancreatic carcinoma with multiple hepatic metastases, peritoneal metastasis, and multiple seedings in the hernia (Pictures 2-4). The diagnosis was Sister Mary Joseph's nodule (SMJN) associated with pancreatic cancer. SMJN is an umbilical metastasis of internal malignancies, such as cancer of the stomach (23%), ovary (17%), colon and rectum (15%), pancreas (9%), and uterus (6%) (1,2). The patient chose to remain at home and ultimately died within six months of the cancer presentation.
Picture 1.

Picture 2.

Picture 3.

Picture 4.

The authors state that they have no Conflict of Interest (COI).
References
- 1. Otsuka I. Cutaneous metastasis after surgery, injury, lymphadenopathy, and peritonitis: possible mechanisms. Int J Mol Sci 20: 3286, 2019. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2. Galvañ VG. Sister Mary Joseph's nodule. Ann Intern Med 128: 410, 1998. [DOI] [PubMed] [Google Scholar]
