Correction to: Nature Reviews Genetics 10.1038/s41576-021-00356-6 published online 13 May 2021.
In the originally published article, the figure for Box 1 (“Germline variants can associate with the same somatic lesion but different levels of phenotypic risk”) showed the JAK2 mutation as JAK2V611F rather than JAK2V617F. This error has now been corrected in the HTML and PDF versions of the article.