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. 2021 Nov 5;26(21):6688. doi: 10.3390/molecules26216688

Figure 3.

Figure 3

(A) Cytotoxicity of 50 μg/mL FOS (organic extract from the inflorescences of Cannabis sativa var. Felina 32 collected in September), and of nonintoxicating phytocannabinoids (17 μg/mL cannabidiol, 6 μg/mL cannabichromene) and caryophyllane sesquiterpenes (0.07 μg/mL α-humulene, 0.1 μg/mL β-caryophyllene, and 0.1 μg/mL β-caryophyllene oxide), at the concentrations determined in the extract by GC-MS analysis, in MDA-MB-468 after 24 h exposure. (B) Cytotoxicity of 17 μg/mL cannabidiol alone and in combination with cannabichromene (6 μg/mL), α-humulene (0.07 μg/mL), β-caryophyllene (0.1 μg/mL), and β-caryophyllene oxide (0.1 μg/mL) in MDA-MB-468 after 24 h exposure. Data are expressed as mean ± SEM of at least three independent experiments with three technical replicates (n = 9); *** p < 0.001, significant difference respect to the control; °° p < 0.01 and °°° p < 0.001, significant difference respect to cannabidiol (ANOVA + Dunnett’s Multiple Comparison PostTest).