Correction: Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment

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Corrections

The legend for Fig. 6 was incorrect in the published article. In the legend for Fig. 6B, “Jurkat cells, which do not…” should read “HeLa cells, which do not…” The corrected figure legend is shown below.

The online version of the article has been corrected and now differs from the print version as originally published.

FIGURE 6. TRAILshort is both necessary and sufficient to cause TRAIL resistance. (A) Jurkat T cells, which constitutively express TRAILshort, were induced to die by the addition of sk-TRAIL, in the presence or absence of increasing amounts of anti-TRAILshort Ab. Cell death was measured by active caspase-3 staining. Control cells were treated with increasing anti-TRAILshort Ab alone. (B) HeLa cells, which do not express TRAILshort, were stimulated to die by the addition of sk-TRAIL in the absence or presence of increasing amounts of a fusion protein consisting of the extracellular domain of TRAILshort fused to Fc (TRAILshort-ECD:Fc) or with BSA control and analyzed as in (A). Additional control cells were treated with increasing TRAILshort-ECD:Fc alone. Data are representative of six independent experiments. p < 0.05 considered statistically significant (linear regression).

In addition, in the last paragraph of the section headed “TRAILshort is necessary and sufficient to cause TRAIL resistance” in Results, the last two sentences should read:

Following purification, TRAILshort-ECD:Fc was added to HeLa cells alone or to HeLa cells treated with sk-TRAIL. Although TRAILshort-ECD:Fc was not toxic, it did prevent sk-TRAIL–mediated killing of HeLa cells in a dose-dependent manner (Fig. 6B).

www.jimmunol.org/cgi/doi/10.4049/jimmunol.1800867

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