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. 2021 Nov 15;16(11):e0259976. doi: 10.1371/journal.pone.0259976

Who am I? Narratives as a window to transformative moments in critical care

Briseida Mema 1,2,¤,*, Andrew Helmers 1,2, Cory Anderson 1, Kyung–Seo (Kay) Min 3, Laura E Navne 4,5
Editor: Filomena Pietrantonio6
PMCID: PMC8592467  PMID: 34780546

Abstract

Critical care clinicians practice a liminal medicine at the border between life and death, witnessing suffering and tragedy which cannot fail to impact the clinicians themselves. Clinicians’ professional identity is predicated upon their iterative efforts to articulate and contextualize these experiences, while a failure to do so may lead to burnout. This journey of self-discovery is illuminated by clinician narratives which capture key moments in building their professional identity. We analyzed a collection of narratives by critical care clinicians to determine which experiences most profoundly impacted their professional identity formation. After surveying 30 critical care journals, we identified one journal that published 84 clinician narratives since 2013; these constituted our data source. A clinician educator, an art historian, and an anthropologist analyzed these pieces using a narrative analysis technique identifying major themes and subthemes. Once the research team agreed on a thematic structure, a clinician-ethicist and a trainee read all the pieces for analytic validation. The main theme that emerged across all these pieces was the experience of existing at the heart of the dynamic tension between life and death. We identified three further sub-themes: the experience of bridging the existential divide between dissimilar worlds and contexts, fulfilling divergent roles, and the concurrent experience of feeling dissonant emotions. Our study constitutes a novel exploration of transformative clinical experiences within Critical Care, introducing a methodology that equips medical educators in Critical Care and beyond to better understand and support clinicians in their professional identity formation. As clinician burnout soars amidst increasing stressors on our healthcare systems, a healthy professional identity formation is an invaluable asset for personal growth and moral resilience. Our study paves the way for post-graduate and continuing education interventions that foster mindful personal growth within the medical subspecialties.

Introduction

“… wanderers in the wilderness of disease hoping to find a path to peace …” (Pinsky, 2013)

Science and Art complement each other in our efforts to better understand the human condition [1]. The effort to examine, reflect upon, and articulate the human experiences of health, sickness, and death, constitutes the field of medical humanities and exemplifies the convergence of Science and Art intrinsic to every clinical encounter [2]. While the entire field of medical humanities shares this goal of applied humanism, it is nevertheless a diverse field, comprised of different perspectives and methodologies which together bring new insights to medical education [3, 4]. In particular, narrative medicine has emerged as a way for clinicians to engage in self-reflection and to frame their medical knowledge within a mindful appreciation of the patient-as-person [57]. Through reflective writing, clinicians examine the personal journeys undertaken by their patients and by themselves, through a process of inquiry, discovery, and analysis [8, 9]. As they navigate challenging situations which transcend textbook knowledge, clinicians learn (and teach, through their writing) how to forge meaning amidst a landscape that is conflicted and emotional more than it is analytic [10, 11]. Writing these narratives becomes a way of reconciling the clinicians’ personal journeys with a profession that can be complex and ambiguous; a way of discovering–and illuminating for others–how to forge a professional identity through reflection on how that profession affects patients and clinicians alike [1214].

The question of what makes someone into the clinician they become never ceases to be relevant in medical education, and perhaps now more than ever before there is an urgency to ask and answer that question. Today’s clinical milieu has become better attuned (albeit imperfectly) to the importance of wellness, moral distress, and burnout among clinicians; and has become (even more imperfectly) cognizant of the determinants of patient care that defy mere medical rote. In this context, medical education must concern itself more consciously with the longitudinal professional identity formation of clinicians at all stages from early training to transitioning out of practice. Narrative writing provides a unique insight (a shared learning) into the transformative experiences which shape clinicians’ professional identity [1518]. There is ample historical precedent for clinicians expressing themselves in fiction and in essays published in the lay and scientific press [1921]. Today’s medical journals are publishing an increasing number of medical narratives, forming a rich syllabus that reflects, shapes and makes visible the iterative process of clinicians’ professional identity. Shared amongst a broader professional community, these narratives provide an opportunity for reflection among individuals with similar experiences; medical educators are thus provided with an opportunity to equip clinicians with a wealth of reflective experiences, to avoid the unexamined life and establish instead a collective self-awareness together with a more holistic understanding of their profession.

We were interested in the professional identity formation of critical care clinicians for the reasons that: (a) they are described to have one of the highest burnout rates [22] and (b) the context of their work typically brings patients and families face-to-face with mortality while blurring the boundaries between human and machine [23, 24]. Intensive care units (ICUs) form the setting for profound life-altering experiences; clinicians, patients and families are constantly challenged to muster the courage and generosity to tolerate and bear witness to unfair losses and tragedies. A comprehensive survey of narratives written by ICU clinicians may offer insight into the way clinicians make sense of their own professional journeys while facing sick and dying patients and help identify core elements relevant to the process of professional identity formation within this environment. The goal of this study was to analyze these narratives, written by ICU clinicians, to answer: What are the experiences shared through narratives that impact ICU clinicians’ identity formation? How is meaning sought in these experiences? What impact do these experiences have upon their personal and professional lives?

Materials and methods

Narratives are published in medical journals, books, blogs, and different websites. Books are written by one author, and we were interested in the community of critical care clinicians. We didn’t have a good method of identifying blogs and other websites and generally they are not peer reviewed, so we focused on narratives published in medical journals. In order to identify pieces published by ICU clinicians, we looked across 30 journals that publish content related to Intensive Care. We looked at each journal’s “Instructions for authors” guidelines to find out if the journal published narrative pieces written by clinicians (S1 Appendix). We found one journal, that consistently published narrative pieces since 2013 in a section titled “From the Inside” [25]. We included all 84 reflective pieces published and these pieces constituted our data source.

Narratives, experiences written in story form, can provide insight into how people make sense of the world and how they communicate their insights to others, providing a “framework for our attempts to come to terms with the nature and conditions of our existence,” as suggested by psychologists Jens Brockmeier and Rom Harre [26]. By conducting a qualitative analysis, using a narrative methodology and thematic data analysis, we sought primarily to understand how the reflective pieces helped the writer make sense of their key experiences [27, 28]. We treated the pieces as narrative pathways to the writer’s identity formation [29]. The choice of a narrative methodology hinged on our preliminary readings of the reflective pieces. We noticed that the point of departure for the majority of these pieces is a transformative moment in a professional’s critical care career, followed by reflections and examples of how such moments have come to shape not only their career paths but also their personal views of their role as clinician in the process of living and dying.

Three research team members: a clinician and educator (BM), a medical anthropologist (LN) and an art historian (KM) participated in the initial coding and data analysis. We recognised that our analyses involved choices made by us–choices about which pieces to highlight or de-emphasize. Using thematic data analysis, we searched across stories for central themes or patterns. Conducting first descriptive and then interpretative coding, we identified major themes and subthemes, and then discussed, revisited, and compared our findings. Findings were discussed and analyses were revised at team meetings until a stable thematic structure was agreed upon. The pieces were frequently re-read throughout the analysis to ensure that the analysis stayed as close as possible to the described experiences and contextual factors that the writers portrayed in their stories. Once the research team agreed upon the thematic structure a clinician and ethicist (AH) and an ICU trainee (CA) read the pieces for analytic validation, to see if they recognized the same themes as central to the writers’ experiences. Member check in was not realistic, considering the pieces were written by more than 100 international clinicians. Our team presented our finding to a group of more than 40 Intensive Care clinicians (doctors, trainees, nurses and respiratory therapists) in our institution and the conclusion was that the finding resonated with them all.

Results

The reflective pieces all begin with transformative moments, encounters which personally challenge the clinician in a way that leads them to discover or re-discover who they are as a person within their profession. The predominant theme across the narratives was the experience of existing at the heart of a dynamic tension between life and death. We identified three further sub-themes: the role dualism; the effort to be the same person on the inside while straddling the divergent worlds of the hospital and the home, and the internal conflict between concurrent but dissonant emotions. These themes are explored below, with illustrative quotations from selected essays in separate tables; our analysis is provided in (S2 Appendix).

Main theme

Existing at the heart of a dynamic tension between life and death

The reflective pieces consistently demonstrate that becoming an ICU clinician usually begins with a strong drive to save lives followed by a gradual realization that their profession has an important role in caring for patients who are dying. The majority of the pieces grapple with the imminence of death.

Life is illuminated by death as a treasure; patients cling to life with “hope against hope”, even when one is breathless, and all the odds are stacked against its continuation. Impending death brings a love for life sharply into focus and lends an urgency to a search for meaning; clinicians become inexorably entangled in the efforts of patients and families to make and preserve memories and to weed out regrets.

In their narratives, clinicians struggle with a “good death”. For some, the ICU can loom as an “arena” where death is fought as a medical condition–contingent, changeable–rather than a tragic reality of the human condition. Clinicians at times are privy to the horror of a prolonged dying process that inflicts progressive “violence” against the person such that death looms as relief from medicine’s machinations.

The narratives grapple with the existential crisis which is a daily reality in critical care: how should I live? How should I die? And the clinicians, facing their own finitude, write about the small but important role they play in a “good death” by respecting the failing body, offering compassion, and relieving suffering. Knowledge and technology cannot stop patients’ tears from falling, but humanism can help wipe tears away.

Faced with death, life takes on added intensity and meaning. The critical care narratives in our study describe how clinicians’ face death with and through their patients, forging a new lens through which they see and shape their own lives, professional and personal. Detailed quotes are provided in Table 1.

Table 1. Quotation for the main theme.
Existing at the heart of a dynamic tension between life and death
Life is something Wild,
Touching your ears,
While your mind tries to puzzle out the honest truth. (Ranzani, 2013)
Hoping against hope in the sea of despair where the hope only floats.
Breathing yet breathless, living yet lifeless. (Kumar, 2014)
Why open your chest to fix what we no longer could?
Why pump on your heart when it no longer would?
I wanted to contest death, and I believed I should. (Gusmao-Flores, 2020)
Every floor is one of several significant illness episodes. On his way down passing each floor, doctors got used to reassuring him saying: “So far so good”. (Elia, 2018)
Modern medicine allows unimagined possibilities to save one’s life and keep death at bay. (Bein, 2018)
But who was my patient? I pause here and acknowledge it was the bleeding, dying boy that I continued to maintain on multiple life-sustaining modalities. (Neville, 2015)
The question may come up ‘‘why is it that it is so hard to die now?” Is it that we have to exhaust all technologies before this is OK? (Bein, 2015)
That ‘‘someday” is today. I am here with you. I won’t leave you. (Benbenishty, 2014)
Caressed by the icy hands, freed from the burning breaths. (Kumar, 2014)
But my humble gratefulness will be for that one
Who was warm and human (Galvez, 2013)
Let me find death Far, far away Into the heart of the mountains. (Hernandez,2013)
Suddenly, the sky was broken by the red horn of the moon emerging from a cloudy horizon in the middle of my solitude. A crescent moon announcing what poets and mystics have claimed for centuries: life goes on no matter how many tragedies you have to endure. (Gorrea, 2013)
Every night can be our last. Make sure that the final goodbye will be a sweet sorrow. I learned this valuable lesson that night, 25 years ago. (Kompanje, 2019)
I had experienced a crucial life event, a sort of epiphany. I had encountered the fascinating alchemy between physiology and humanism. (Hernandez, 2013)
And yet, sometimes, often times, it is not practical medical acumen that serves my patients well, but rather a pure and simple compassion … wanderers in the wilderness of disease hoping to find a path to peace that if it could not mean recovery at least would not mean pain and distress. (Pinsky, 2013)

Subtheme 1

Role dualism

The tension between life and death in critical care is sometimes experienced as a mirror rather than a lens; every clinician experiences for themselves and for their loved ones, moments where they assume a patient’s role. These moments challenge and refine professional identity as clinicians witness and support suffering and grief while counting themselves among those who suffer and grieve. Experiencing medicine as a patient or patient-partner brings an enhanced awareness of the limits of medicine; judgments, predictions, objectivity–all of these professional habits are examined anew.

Tasked with high-stakes decisions about individuals’ destinies in charged situations, clinicians reflect on the limits of their abilities and ask, what is humanly possible? Is it a human task to be able to answer the patient’s questions: “am I going to die?” or “am I dead?” upon their awakening from coma? Does it require superhuman abilities to make judgements about quality of life and to decide when death is the “better option” in the face of ambiguity? Occupying the liminal space between self-confidence and doubt, the analytical and the emotional, clinicians have the unique opportunity to bridge the gap between objective data and human emotion. These clinicians gather the courage to recognize the superior role of chance and context and take responsibility for the margin of difference their choices can make. Though some decisions may seem too difficult or inhumane it is an uncomfortable reality that these decisions can only be made by humans.

As patients themselves, as caregivers for a sick loved one, and as a consequence of empathy, clinicians find their professional habits tempered by personal humility. These dual experiences–to diagnose and to seek a diagnosis, to care and be cared for, to grieve with and to grieve for, to trust and to seek trust–become an opportunity for clinicians to affirm their profession as a vocation, strengthening their ability and capacity to “suffer with” that is intrinsic to compassion. Their role dualism thus becomes a way to help their patients navigate the dying process. Detailed quotes are provided in Table 2.

Table 2. Quotation for the sub-theme 1: Role dualism.
I froze as a sudden unwelcome surge of panic welled up inside of me and shattered my line of thought like a hammer hitting glass. She was my daughter. (Maclaren, 2013)
What is it like to grieve while working in the ICU? Is it possible to rise from the depths of your personal loss and help others? (Mema 2020)
It obliges us to deliver potentially devastating news about prognosis directly to an ill patient. In the process, we must face our own apprehensions about navigating difficult conversations and perhaps even contemplating our own mortality. (Isaac, 2017)
…frequently faced with judgements regarding the burdens and benefits of continuing artificial support—and life itself. (Koch, 2017)
Up to what point could the confidence we have in such prognosis—in clear conscience—legitimately modify the future of a piece of the mankind we have in our charge, represented by a single individual destiny? (Gobert, 2016)
Two patients showed me their capability to predict time of death without any knowledge of complicated scoring systems or many years of clinical experience. (Bakker, 2013)
This gives us the illusion of being able to fully control the biological aspects of our patients’ existence. It almost appears that their lives depend on our interventions and decisions (Elia, 2018)
realized that choice was an illusion. (Maringer, 2018)
. crucial to find the balance between compulsive technological care or just listening to the patient’s dreams. This was Don Dago for me, a man who lived and died like he wanted to. (Sánchez, 2014)
The shield that had allowed me to maintain a safe distance from the suffering around me was shattered, and I felt the sobering but no longer suffocating weight of responsibility that my profession conferred on me. (Gristina, 2013)
I cried. My “empathic filter” had failed completely. (Kompanje, 2019)

Subtheme 2

Bridging two worlds

The Intensive Care Unit is a surreal place, its sights and sounds combining last century’s anachronisms side-by-side with the stuff of science fiction. Clinicians work long hours in this place, and witness patients and families occupy an unnatural permanence in what is “meant” to be a transient waystation. For clinicians and patients alike, the ICU warps time and space: in one bed, time does not pass and becomes monotonous, the minutes resemble days with the unbearable disappointment that one is still in bed, still immobilized, physically or mentally; in the next bed, an emergency, where seconds of indecision or minutes of high-stakes work can seem like an eternity. The lights are always on, the patients and their families are always embroiled in the most important and even the final struggle of their life together. Clinicians’ professional and personal lives can seem worlds apart; their journey home each day can feel like they hold a privileged return ticket for the ferry across the Styx. On one shore: the monumental, the beatific, technology, extraordinary; on the other, the mundane, the banal, humane, personal.

Clinicians’ narratives speak of their fraught efforts to assert personhood as a professional, to bring something personal into the impersonal tangle of machines at the bedside, to build bridges that preserve a single identity at home and in the hospital both for themselves and for their patients. Some invoke art and music, one brings a “swimming pool” for a bedside baptism, one helps bring an intubated child home for Christmas against the “rules”; together they speak to the importance of affirming personal identity and meaning amidst what can be a disorienting professional environment. This effort to be (and empower being) in a way that is not defined by the hospital environment becomes a defining part of the clinician-narrators’ professional identity, a way of seeing patients and families that transcends the accoutrements of acute care medicine. Detailed quotes are provided in Table 3.

Table 3. Quotation for the sub-theme 2: Bridging Two Worlds.
There was what I could perceive of the real world around me, and then there was my dream world. (Fenn, 2014)
The sick, whom we shepherd through the shards of night, dream their jittery dreams, unconscious, scissor-step from light to nightmare and back again. (Butka, 2014)
“It’s not her time,” everyone said.
A full month since the hit-and-run,
We gave her a life, in an ICU bed. (Yan, 2019)
We are like in a submarine? He shows that there are no windows, no natural light, and no knowledge of night or day—no landmarks. (Nguyen, 2018)

Subtheme 3

Emotional disparity

Critical care clinicians experience and witness a myriad of emotions throughout each day–walking from room to room in the ICU might mean moving from a death vigil to a patient ready for discharge. Rooms become haunted with memories of patients’ mortality, each death and each “triumph” leaving an inexorable mark. Such memories remain vivid after many years, and so the cacophony of daily emotions in the present are joined and shaped by emotions past: hope, despair, attachment, detachment, joy, and grief.

Clinicians maintain hope while facing a new reality by recalibrating, looking at life and disease with a new perspective; but hope in critical care is a vulnerable thing, haunted by despair and regret. Joy emerges with a new intensity from situations that seemed hopeless but it cannot always shake the shadows of uncertainty and doubt.

In this tense context, clinicians feeling detachment may seem more protected from this vulnerability but still naturally get attached to their patients and “crave” to know the human in the ICU bed. Acknowledging the incomplete, fragile connection to their patients, they use music, touch and other forms of non-verbal communication that might reach their patients. They explore their fears and pains and try to relieve them and ascribe a personality to their patients. Sometimes these clinicians write biographies for their patients, depending on relatives to fill in the blanks or, if relatives are absent, becoming a kind of relative themselves. Clinicians find a way to deal with their own grief for the loss of a patient, often transforming it into personal growth, learning, and empathy.

Though the burden of conflicting emotions weighs heavily, many of the narratives invoke a concomitant sense of fulfillment, which stems from being able to support dying patients and their families, or accompanying them through their most vulnerable times, or helping a patient put on their shoes and witnessing them take their first walk after a long “pause.” Fulfillment drives clinicians’ resilience–their longevity within and dedication to this necessarily intense but fulfilling career. Detailed quotes are provided in Table 4.

Table 4. Quotation for the sub-theme 3: Emotional Disparity.
…many times we want to turn around the inescapable course of the events. Somehow, someway, we get some hints that seem to endorse our innermost longings. (Castro, 2014)
It was so much easier then to hold your quiet hand
than it is now to keep your spirit standing tall.
But I am still here despite it all, always
sitting by your side. (Struwing, 2015)
I help her put on her socks and soft shoes, although she does not like the fold of the socks and asks me to fix them. As I am doing this, she is looking at me with approval and a knowing glance that she is ready to begin. (Polastri, 2015)
We stayed there to show respect. To recognize the girl who was there. To remember her life and laughs. Through silence, we tried to emphasize the brevity and importance of that moment. Because she deserved it as a human being. (Garcia-Salido, 2019)
We stopped rounds in front of room number seven as a signal of respect. We felt so sad and empty. So many weeks with us, and we barely knew this man—his dreams, hopes, and fears. (Hernandez, 2019)

Discussion

We sought to examine longitudinal Professional identity formation (PIF) by analyzing narratives written by clinicians–trainees and senior learners alike–within Critical Care Medicine, a speciality that is responsible for some of the highest rates of burnout among its staff [30, 31]. It is an elemental and disquieting fact that we all will cease to exist at some point; however, for most it temporarily remains an abstraction facilitated by being caught up in the urgent matters of living. Forced by the circumstances of their profession, these clinicians meet the imposing reality of death and their professional demands living in the heart of the tension between life and death. To manage this tension requires living among opposing forces, events, roles, emotions, and contexts.

Our study adds to the literature in several ways. First, while PIF is described as a longitudinal and complex lifelong process, the majority of studies to date have focused on medical students [3235]. The 84 reflective pieces in our analysis provide rich examples of key transformative experiences that impact the professional identity formation of this group of clinicians while they reflect on critical formative experiences to construct meaning and clarify values as individuals within their profession. Our analysis thus uncovers an important framework for medical educators to foster PIF within Critical Care, and also establishes a unique means by which other medical specialties can also add to their understanding of PIF.

Identity conflicts (demonstrated in roles, contexts, and emotions) can be a source of “tension” as personal meets professional and one strives for an idealized professional self. As evolving professionals confront new realities of medical practice that depart from their initial expectations, they must adapt and reconcile the “ideal” and lived versions of professional identity. Working at the center of these tensions can be disorienting and exhausting. There will always be the temptation to disconnect and retreat, to distance oneself from existential turmoil, and even to treat death as if it constitutes an adverse event. But the tension itself never disappears, and to ignore it is to risk the loss of perspective and professional integrity to which clinicians strive. These clinicians write about how they seek to live in this tension: to master it before it masters them; as a group, their pieces resemble “coming-of-age” stories with protagonists who undergo psychological and moral growth through their experience of the tempest that is clinical care. The narratives in our study promote an understanding of the transformation intrinsic to professional identity formation, holding up a mirror to each of us by articulating what it means to navigate those essential day-to-day tensions that challenge clinicians to question and renew their core values.

Concerns about burnout in critical care clinicians in particular and the medical community as a whole are growing rapidly, and many societies are calling for action [30, 31]. Research and policy development to address burnout are constrained by the inability to eliminate morally and emotionally challenging situations in the clinical realm; to truly mitigate burnout, medical practice must foster professional growth and moral resilience [36]. Professional identity formation has been associated with the development of an “inner compass” in trainees and practicing clinicians, together with resilience [3741]. The goal of professional identity formation has been described as “to anchor students to foundational principles while helping them navigate the inevitable moral conflicts in medical practice” [42]. Role models, mentors and accumulation of clinical experiences are the most powerful factors that influence professional identity formation [16, 43, 44]. Transformative learning represents one process through which learners make sense of their key professional experiences; such learning utilizes reflections such as the narratives in our study, facilitated by a role model, mentor, or a peer group [11, 40, 45].

Our analysis engages with a complete, albeit relatively small, corpus of reflective narratives by intensive care professionals and highlights a shared exploration of the tension at the heart of the clinical work. These narratives serve as inspiration for ways in which intensive care trainees may be introduced to the field. The tensions described within these narratives reflect the common and disorienting experiences that impact professional identity formation, the raw material for medical educators to engage with as mentors and role models to guide reflection and to enrich each clinician’s perspective [45]. Exposing these crucial moments provides opportunities to anticipate and support positive professional identity development. Moreover, such narrative writing may offer a vehicle for formal teaching; these pieces challenge each clinician to confront their clinical terrain, to chart a course consistent with who they are as a professional who sits across from their patient as a fellow traveller [46].

There are a few limitations to our study. First, our focus on a particular group might be construed as a limitation; however, the themes contained in our analysis will likely resonate beyond the field of Critical Care. Further, the authors of these pieces transcend the institutional and geographic barriers typical of most research, and thus reflect a further generalizability. We recognise that personal stories published in a journal are written for a particular audience, namely health professionals and colleagues who conceivably have a shared understanding of the exigencies of the critical care profession. Moreover, we recognized that such stories will necessarily differ from those told to other audiences. At the same time, all narratives, including those gathered from selected journals, are incomplete and received differently over time, according to their context and by each reader. We acknowledge that this is a special group of individuals for many reasons: they are willing to share their dilemmas, challenges, and vulnerabilities with a readership of their peers; they are able to comprehend and analyze their feelings and express them beautifully; they describe key events that shape and transform the writer; and they analyze events and experiences as part of the larger picture of the clinician’s emotional education beyond the personal parameters of the event. These individuals are also able to produce well-written narratives and use literary devices and a knowledge of literature to articulate their lives as art. In doing so, they shift the reader’s perspectives and broaden their understanding. Finally, we realize that these pieces are selected and revised by external editors–nevertheless, it would be difficult to obtain a deliberate sampling of intensive care clinicians’ writing, as many would not embrace this mode of expression for their inner reflections.

Conclusions

In summary, our study provides insight into the longitudinal professional identity formation of clinicians working in intensive care. Utilizing narratives to make sense of complex human experiences, our analysis captures the way in which critical care clinicians build a mature understanding of their profession through transformative experiences. The themes identified herein can serve as a novel resource for medical educators, colleagues and leaders to build supportive, effective, and healthy interventions to foster emotional and moral resilience. It is our hope that the analysis we employed be emulated within other medical specialties in order to enhance their understanding and support professional identity formation, and that medical humanities in general be invoked to better understand the values essential for sustainable patient care.

Supporting information

S1 Appendix. List of journals that publish content related to Critical Care Medicine with corresponding website.

(DOCX)

S2 Appendix. Analyzes of narratives written by ICU clinicians.

(Narratives were published in the section “From the Inside”, Intensive Care Medicine Journal).

(DOCX)

Data Availability

All relevant data are within the paper and its Supporting Information files.

Funding Statement

BM received the Medical Humanities Education Grant, 2020 from the University of Toronto.The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Decision Letter 0

Filomena Pietrantonio

9 Aug 2021

PONE-D-21-09314

Who Am I? Narratives as a Window to Transformative Moments in Critical Care

PLOS ONE

Dear Dr. Briseida Mema,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Interesting study that explores a field of Narrative Medicine in Critical Care with a new approach.

However, to be publishable on PLOSONE it is necessary that the Authors answer the following points:

  1. To respond accurately to the Reviewers’ requests

  2. To improve the methodology of the proposed study

  3. To better define the study design

  4. To highlight how the results of the study can be valid in contexts other than the one where the study was carried out.

  5. Please use specifing reporting guideline and adhere to either COREQ, SRQR, or any other applicable EQUATOR guideline.

  6. Please Explain in the Discussione the acronym PIF.

  7. Please include the Limitations and Conclusions paragraphs in the paper

  8. To improve the bibliography by adding more recent studies on the subject.

Thedecision is justified on PLOS ONE’s publication criteria.

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We look forward to receiving your revised manuscript.

Kind regards,

Filomena Pietrantonio

Academic Editor

PLOS ONE

Additional Editor Comments (if provided):

Interesting study that explores a field of Narrative Medicine in Critical Care with a new approach.

However, to be publishable on PLOSONE it is necessary that the Authors answer the following points:

1. To respond accurately to the Reviewers’ requests

2. To improve the methodology of the proposed study

3. To better define the study design

4. To highlight how the results of the study can be valid in contexts other than the one where the study was carried out.

5. Please use specifing reporting guideline and adhere to either COREQ, SRQR, or any other applicable EQUATOR guideline.

6. Please Explain in the Discussione the acronym PIF.

7. Please include the Limitations and Conclusions paragraphs in the paper

8. To improve the bibliography by adding more recent studies on the subject.

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When submitting your revision, we need you to address these additional requirements.

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"Bm received the Medical Humanities Education Grant, 2020 from the University of Toronto. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. "

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[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Partly

Reviewer #2: Yes

**********

2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: N/A

Reviewer #2: N/A

**********

3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The paper consists in an analysis of a selection of narratives published on a single journal.

I found the paper interesting and pleasant to be read; several statements and quotations resonated with my own ED past practice.

However, while the paper seems flow and reasonable, it is lacking on the methodological side, expecially regarding data sources selection. Moreover, current journal policies mandate that Qualitative research must adhere to appropriate study design and reporting guidelines.

Here are some points for the Authors to be considered;

1) No effort has been reported for bias reduction strategies (expecially given the high risk of involuntary or inconscious cherry-picking) in choosing narratives to be included or excluded;

2) Consistently, reported narratives were focused on single episodes ("transformative moments"), usually with recurrent elements of tension (as seen in Appendix 2). However, no explanation is given on the absence of tension-less narratives - do such situations simply not happen, or is there any publication bias towards specific kinds of narrative? Altought this last question does not directly relate in the study objectives, the possibility should be at least mentioned in the dicussion section.

3) No information has been given on the number of narrative excluded from the study, nor on inclusion criteria.

4) Study design is not well defined, lacking a well formalized objective. Analyzing a selection of published clinicians' pieces "to determine which experiences most profoundly impacted their professional identity formation" is a rather ambitious objective given the design did not follow a systematic approach.

5) No quality assesment of retrieved pieces was performed.

6) Authors mentioned to have performed a search on 30 different journals. No methodology for such selection has been described.

7) No effort has been described in expanding selecion in languages different than English, or grey literature; sources such as blogs, articles and papers can be found aswell. For instance, an example of narrative collection in the same field of emergency medicine can be found here after a quick google search: https://litfl.com/anthology/literary-medicine-musings/.

9) No specifing reporting guideline has been used, in contrast with Journal policies. Please adhere to either COREQ, SRQR, or any other applicable EQUATOR guideline.

I believe that none of the mentioned points (beside last one) is per se obstative to article acceptance, however they all contribute to expose the work to a significant risk of bias in its conduction and conclusions.

Reviewer #2: dear, I read with interest your paper. I appreciate your work. many thanks for your work and fot time that you spent. In my personal opinion narrative medicine in not properly considered by clinicians.

**********

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Reviewer #1: Yes: Antonio Vinci

Reviewer #2: Yes: francesco rosiello

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PLoS One. 2021 Nov 15;16(11):e0259976. doi: 10.1371/journal.pone.0259976.r002

Author response to Decision Letter 0


29 Aug 2021

EDITOR COMMENTS:

Interesting study that explores a field of Narrative Medicine in Critical Care with a new approach. However, to be publishable on PLOSONE it is necessary that the Authors answer the following points:

1. To respond accurately to the Reviewers’ requests

Response 1: Thank you. We have done that in detail below.

2. To improve the methodology of the proposed study

Response 2: Our responses to Reviewer 1, our edits, and our inclusion of the “Reporting Guidelines” demonstrate a study with a sound methodology.

3. To better define the study design

Response 3: We conducted a qualitative analysis, using a narrative methodology and thematic data analysis, we sought primarily to understand how the reflective pieces helped the writer make sense of their key experiences and influenced their professional identity formation.

4. To highlight how the results of the study can be valid in contexts other than the one where the study was carried out.

Response 4: Using published narratives, our findings were based on analyzing reflections of more than 100 international clinicians across all continents, written through 8 years. We didn’t collect reflections of clinicians in a single institution at a single time point. Our results are therefore valid in many different contexts (spanning over time, space, people).

5. Please use specifing reporting guideline and adhere to either COREQ, SRQR, or any other applicable EQUATOR guideline.

Response 5: We have included the Table at the very end of this document.

6. Please Explain in the Discussion the acronym PIF.

Response 6: We have explained Professional Identity Formation (PIF) at the beginning of the Discussion.

7. Please include the Limitations and Conclusions paragraphs in the paper

Response 7: There is a Limitations and Conclusions paragraph in our manuscript.

8. To improve the bibliography by adding more recent studies on the subject.

Response 8: The following References have been added throughout the manuscript:

Jowsey T, et al. Performativity, identity formation and professionalism: Ethnographic research to explore student experiences of clinical simulation training. PLoS One. 2020 Jul 30;15(7):e0236085.

Wald HS, Ruddy M. Surreal Becomes Real: Ethical Dilemmas Related to the COVID-19 Pandemic and Professional Identity Formation of Health Professionals. J Contin Educ Health Prof. 2021 Apr 1;41(2):124-129.

Stetson GV, Kryzhanovskaya IV, Lomen-Hoerth C, Hauer KE. Professional identity formation in disorienting times. Med Educ. 2020 Aug;54(8):765-766.

Findyartini A, Anggraeni D, Husin JM, Greviana N. Exploring medical students' professional identity formation through written reflections during the COVID-19 pandemic. J Public Health Res. 2020 Nov 17;9(Suppl 1):1918.

Khoo SM, Serene WXL. When Faculty Tell Tales: How Faculty Members' Reflective Narratives Impact Residents' Professional Identity Formation. Acad Med. 2021 Jul 27.

Lawrence EC, Carvour ML, Camarata C, Andarsio E, Rabow MW. Requiring the Healer's Art Curriculum to Promote Professional Identity Formation Among Medical Students. J Med Humanit. 2020 Dec;41(4):531-541.

REVIEWER #1:

The paper consists in an analysis of a selection of narratives published on a single journal. I found the paper interesting and pleasant to be read; several statements and quotations resonated with my own ED past practice.

However, while the paper seems flow and reasonable, it is lacking on the methodological side, especially regarding data sources selection. Moreover, current journal policies mandate that Qualitative research must adhere to appropriate study design and reporting guidelines.

Here are some points for the Authors to be considered;

Comment 1: No effort has been reported for bias reduction strategies (especially given the high risk of involuntary or unconscious cherry-picking) in choosing narratives to be included or excluded.

Response 1:

Thank you. As explained in our methods section in the manuscript we report carefully how we have chosen and included narratives from the only journal consistently publishing narrative pieces since 2013. Furthermore, we did not pick among the 84 pieces from the journal but included them all: “In order to identify pieces published by ICU clinicians, we looked across 30 journals that publish content related to Intensive Care. We looked at each journal’s “Instructions for authors” guidelines to find out if the journal published narrative pieces written by clinicians (Supplemental Digital Appendix 1). We found one journal, that consistently published narrative pieces since 2013 in a section titled “From the Inside”25. These 84 reflective pieces constituted our data source.”

Concerning the comment on our lack of “reporting bias reduction strategy”. Our study follows the ontology of qualitative research and thus a social constructivist view in which personal “bias” is a condition of possibility and the assessment of the quality of research must instead hinge on the transparency as to how data was selected (see for instance Stige et al 2009).

We have described clearly that we were very inclusive of narratives published in Intensive Care journals. We included all the ones that were published therefore we did not “cherry pick”. We have edited the last sentence to more clearly portray that:

We found one journal, that consistently published narrative pieces since 2013 in a section titled “From the Inside”25. We included all 84 reflective pieces published and these pieces constituted our data source.”

Comment 2: Consistently, reported narratives were focused on single episodes ("transformative moments"), usually with recurrent elements of tension (as seen in Appendix 2). However, no explanation is given on the absence of tension-less narratives - do such situations simply not happen, or is there any publication bias towards specific kinds of narrative? Although this last question does not directly relate in the study objectives, the possibility should be at least mentioned in the discussion section.

Response 2:

Thank you for this interesting comment. Narratives are reflective pieces. Reflection is “a term for those intellectual and affective activities in which individuals engage to explore their experiences in order to [gain] a new understanding and appreciation.”, as such narratives are bound to be about transformative moments. We see this comment as related to “comment 1” about bias in selection strategies. We agree that we did make analytical choices in what themes we present as central across the narratives. However, the analytical process of how we found those themes and the large transdisciplinary group (5 of us with different backgrounds) that helped validate the selection of themes is described clearly on the Methods section: “Three research team members: a clinician and educator (BM), a medical anthropologist (LN) and an art historian (KM) participated in the initial coding and data analysis… Once the research team agreed upon the thematic structure a clinician and ethicist (AH) and an ICU trainee (CA) read the pieces for analytic validation, to see if they recognized the same themes as central to the writers’ experiences.” In particular, the choice to focus on tensions as opposed to tension-less narratives followed the tendency in the empirical material in which the majority of the narratives presented narratives centering on tensions around life-and-death (see main theme on the result section).

Additionally, to strengthen the analysis, we presented our findings to our multidisciplinary group (Intensive Care doctors, trainees, nurses and respiratory therapist) to see of the findings resonated with them. In our presentation there were 40 participants and even though they didn’t write these pieces, our findings resonated with all. To strengthen our analysis, we have added this sentence to the result section to include the result of the presentation:

“Member check in was not realistic, considering the pieces were written by more than 100 international clinicians. Our team presented our finding to a group of more than 40 Intensive Care clinicians (doctors, trainees, nurses and respiratory therapists)in our institution and the conclusion was that the finding resonated with them all.”

Comment 3: No information has been given on the number of narratives excluded from the study, nor on inclusion criteria.

Response 3:

We have clarified in the methods section how we wanted to include all narratives written by Intensive Care Clinicians. We have explained in the response to you in Comment 1 and by editing one of the sentences that we didn’t exclude any narratives (we included all the published pieces).

Comment 4: Study design is not well defined, lacking a well formalized objective. Analyzing a selection of published clinicians' pieces "to determine which experiences most profoundly impacted their professional identity formation" is a rather ambitious objective given the design did not follow a systematic approach.

Response 4:

Thank you for this comment. We agree that the word “profoundly” is maybe not the right word here, so we changed it to:

“What are the experiences shared through narratives that impact ICU clinicians’ identity formation?”

We did follow a systematic approach in selection of the pieces as well as our analysis of the pieces. We have clearly described that in our “Material and Methods” and furthermore in our completed table that goes over the checklist of Standards for reporting Qualitative Research.

Comment 5: No quality assessment of retrieved pieces was performed.

Response 5:

Thank you for this comment. We understand that we have embarked on a quest that has not yet been embarked on. This study is not a classic, quantitative “literature review” and the narratives of these clinicians do not report on original research data and have not applied any research methodology. The only assessment of these pieces is that: they describe key professional moments that have moved the authors and they have gone peer review by the journal that published them. We should be careful not to make “quality assessments” of such personal narratives. Quantifiable markers of achievement could be detrimental to what narratives aims to achieve and as mentioned by some authors “the very essence and purpose of reflection may be compromised when it is enforced in an overly prescriptive manner, or when it is subjected to formal evaluation” (Ng et al. Med Edu 2015; 49: 461-75).

Comment 6: Authors mentioned to have performed a search on 30 different journals. No methodology for such selection has been described.

Response 6:

In our “Materials and Methods” we describe: “In order to identify pieces published by ICU clinicians, we looked across 30 journals that publish content related to Intensive Care. We looked at each journal’s “Instructions for authors” guidelines to find out if the journal published narrative pieces written by clinicians (Supplemental Digital Appendix 1).”

Again, our study is not a conventional Literature Review. Our study is a Qualitative Research Study using qualitative data. We had two choices. We could have asked clinicians in our center to write narratives and personal reflections but that would have been a limited data source and most would not embrace these type of writing.

Published narratives were then rich sources of data for the following reasons: (a) They are written through almost a decade, (b) they were written from more than 100 clinicians across all continents, (c) the pieces have undergone peer review.

When deciding to use published narratives we decided to look at medical journals and since we were focused on Critical Care, we looked at journals that published Critical Care content. Other narratives would be books and books being massive texts written by only one person, wouldn’t be rich sources of data, they would represent the view of one person only. Blogs are generally not peer reviewed.

Our selection of pieces is not a conventional methodology, but it is a very innovative way of getting rich qualitative data that spans geographical boundaries through almost a decade and have been reviewed by peers.

We have also added the following paragraph in Materials and Methods:

“Narratives are published in medical journals, books, blogs, and different websites. Books are written by one author, and we were interested in the community of critical care clinicians. We didn’t have a good method of identifying blogs and other websites and generally they are not peer reviewed, so we focused in narratives published in medical journals.”

Comment 7: No effort has been described in expanding selecion in languages different than English, or grey literature; sources such as blogs, articles and papers can be found aswell. For instance, an example of narrative collection in the same field of emergency medicine can be found here after a quick google search: https://litfl.com/anthology/literary-medicine-musings/.

Response 8:

Again, this is not a systematic literature review. In Qualitative study an important issue is whether you have data saturation or not and most certainly we did. If we didn’t have a thematic saturation, we were going to look into other sources of data. In general, most qualitative studies report a thematic saturation with 10-15 interviews, in our case we had 84 reflections written by more than 100 participants.

Comment 9: No specifying reporting guideline has been used, in contrast with Journal policies. Please adhere to either COREQ, SRQR, or any other applicable EQUATOR guideline.

Response 9:

Thank you! Please see our Table at the end of this document.

Comment 10: I believe that none of the mentioned points (beside last one) is per se obstative to article acceptance, however they all contribute to expose the work to a significant risk of bias in its conduction and conclusions.

Response 10:

Thank you! We hope that our responses and edits have clarified your points and have made the article better.

REVIEWER #2:

Dear, I read with interest your paper. I appreciate your work. many thanks for your work and fot time that you spent. In my personal opinion narrative medicine in not properly considered by clinicians.

Response:

Thank you! We agree with you fully on the value of Narrative Medicine.

Standards for Reporting Qualitative Research (SRQR)*

http://www.equator-network.org/reporting-guidelines/srqr/

Page/line no(s).

Title and abstract

Title - Concise description of the nature and topic of the study Identifying the study as qualitative or indicating the approach (e.g., ethnography, grounded theory) or data collection methods (e.g., interview, focus group) is recommended 1

Abstract - Summary of key elements of the study using the abstract format of the intended publication; typically includes background, purpose, methods, results, and conclusions 2-3

Introduction

Problem formulation - Description and significance of the problem/phenomenon studied; review of relevant theory and empirical work; problem statement 5-6

Purpose or research question - Purpose of the study and specific objectives or questions 5-6

Methods

Qualitative approach and research paradigm - Qualitative approach (e.g., ethnography, grounded theory, case study, phenomenology, narrative research) and guiding theory if appropriate; identifying the research paradigm (e.g., postpositivist, constructivist/ interpretivist) is also recommended; rationale** 6-7

Researcher characteristics and reflexivity - Researchers’ characteristics that may influence the research, including personal attributes, qualifications/experience, relationship with participants, assumptions, and/or presuppositions; potential or actual interaction between researchers’ characteristics and the research questions, approach, methods, results, and/or transferability 7

Context - Setting/site and salient contextual factors; rationale** n/a

Sampling strategy - How and why research participants, documents, or events were selected; criteria for deciding when no further sampling was necessary (e.g., sampling saturation); rationale** 6

Ethical issues pertaining to human subjects - Documentation of approval by an appropriate ethics review board and participant consent, or explanation for lack thereof; other confidentiality and data security issues n/a

Data collection methods - Types of data collected; details of data collection procedures including (as appropriate) start and stop dates of data collection and analysis, iterative process, triangulation of sources/methods, and modification of procedures in response to evolving study findings; rationale** 6-7

Data collection instruments and technologies - Description of instruments (e.g., interview guides, questionnaires) and devices (e.g., audio recorders) used for data collection; if/how the instrument(s) changed over the course of the study n/a

Units of study - Number and relevant characteristics of participants, documents, or events included in the study; level of participation (could be reported in results) 6

Data processing - Methods for processing data prior to and during analysis, including transcription, data entry, data management and security, verification of data integrity, data coding, and anonymization/de-identification of excerpts 6-7

Data analysis - Process by which inferences, themes, etc., were identified and developed, including the researchers involved in data analysis; usually references a specific paradigm or approach; rationale** 6-7

Techniques to enhance trustworthiness - Techniques to enhance trustworthiness and credibility of data analysis (e.g., member checking, audit trail, triangulation); rationale** 7

Results/findings

Synthesis and interpretation - Main findings (e.g., interpretations, inferences, and themes); might include development of a theory or model, or integration with prior research or theory 7-15

Links to empirical data - Evidence (e.g., quotes, field notes, text excerpts, photographs) to substantiate analytic findings 9/11/13/15

Discussion

Integration with prior work, implications, transferability, and contribution(s) to the field - Short summary of main findings; explanation of how findings and conclusions connect to, support, elaborate on, or challenge conclusions of earlier scholarship; discussion of scope of application/generalizability; identification of unique contribution(s) to scholarship in a discipline or field 15-19

Limitations - Trustworthiness and limitations of findings 18

Other

Conflicts of interest - Potential sources of influence or perceived influence on study conduct and conclusions; how these were managed 1

Funding - Sources of funding and other support; role of funders in data collection, interpretation, and reporting 1

*The authors created the SRQR by searching the literature to identify guidelines, reporting standards, and critical appraisal criteria for qualitative research; reviewing the reference lists of retrieved sources; and contacting experts to gain feedback. The SRQR aims to improve the transparency of all aspects of qualitative research by providing clear standards for reporting qualitative research.

**The rationale should briefly discuss the justification for choosing that theory, approach, method, or technique rather than other options available, the assumptions and limitations implicit in those choices, and how those choices influence study conclusions and transferability. As appropriate, the rationale for several items might be discussed together.

Reference:

O'Brien BC, Harris IB, Beckman TJ, Reed DA, Cook DA. Standards for reporting qualitative research: a synthesis of recommendations. Academic Medicine, Vol. 89, No. 9 / Sept 2014

DOI: 10.1097/ACM.0000000000000388

Attachment

Submitted filename: Response to Reviewers .docx

Decision Letter 1

Filomena Pietrantonio

2 Nov 2021

Who Am I? Narratives as a Window to Transformative Moments in Critical Care

PONE-D-21-09314R1

Dear Dr. Briseida Mema,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Filomena Pietrantonio

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

The authors have addressed all comments in a satisfactory way.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

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Reviewer #1: All comments have been addressed

Reviewer #2: All comments have been addressed

**********

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The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Yes

**********

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Reviewer #1: N/A

Reviewer #2: N/A

**********

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Reviewer #1: Yes

Reviewer #2: Yes

**********

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PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: The authors have addressed all comments in a satisfactory way

I believe the paper can be accetted for publication.

Reviewer #2: thank you for your work. I appreciate the revised draft. I hope to read the published article soon!!

**********

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Reviewer #1: Yes: Antonio Vinci

Reviewer #2: No

Acceptance letter

Filomena Pietrantonio

4 Nov 2021

PONE-D-21-09314R1

Who Am I? Narratives as a Window to Transformative Moments in Critical Care

Dear Dr. Mema:

I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS ONE. Congratulations! Your manuscript is now with our production department.

If your institution or institutions have a press office, please let them know about your upcoming paper now to help maximize its impact. If they'll be preparing press materials, please inform our press team within the next 48 hours. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information please contact onepress@plos.org.

If we can help with anything else, please email us at plosone@plos.org.

Thank you for submitting your work to PLOS ONE and supporting open access.

Kind regards,

PLOS ONE Editorial Office Staff

on behalf of

Dr. Filomena Pietrantonio

Academic Editor

PLOS ONE

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    S1 Appendix. List of journals that publish content related to Critical Care Medicine with corresponding website.

    (DOCX)

    S2 Appendix. Analyzes of narratives written by ICU clinicians.

    (Narratives were published in the section “From the Inside”, Intensive Care Medicine Journal).

    (DOCX)

    Attachment

    Submitted filename: Response to Reviewers .docx

    Data Availability Statement

    All relevant data are within the paper and its Supporting Information files.


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