Skip to main content
. 2021 Nov 16;12(6):e02425-21. doi: 10.1128/mBio.02425-21

FIG 4.

FIG 4

Regulation of iron-sulfur cluster synthesis in Escherichia coli. (A) X-ray structure of an apo-IscR monomer with the proposed Fe-S cluster ligands (C92A, C98A, C104A, and H107) highlighted in red (PDB accession number 4HF1). Note that in this IscR variant, the ligating cysteines have been changed to alanines. (B) X-ray structure of dimeric apo-IscR bound to the hya promoter, which is a type 2 binding site (PDB accession number 4HF1). Each monomer is differently colored (blue and pink). (C) Model for the regulation of ISC and SUF expression in Escherichia coli.