Table 1. Baseline Characteristics of Patients Enrolled in PARALLAX-HF.
| Characteristics | No. (%) of patients | |
|---|---|---|
| Sacubitril/valsartan (n = 1281) | Background medication–based individualized comparator (n = 1285) | |
| Age, y | ||
| Mean (SD) | 72.9 (8.4) | 72.4 (8.6) |
| ≥65 | 1085 (84.7) | 1064 (82.8) |
| Sex | ||
| Women | 643 (50.2) | 658 (51.2) |
| Men | 638 (49.8) | 627 (48.8) |
| Racea | ||
| Asian | 56 (4.4) | 59 (4.6) |
| Black | 11 (0.9) | 16 (1.3) |
| Native American | 39 (3.0) | 33 (2.6) |
| White | 1112 (86.8) | 1117 (86.9) |
| Otherb | 63 (4.9) | 59 (4.6) |
| Geographical region | ||
| Europe | 970 (75.7) | 969 (75.4) |
| Latin America | 177 (13.8) | 179 (13.9) |
| Asia-Pacific or other | 69 (5.4) | 70 (5.5) |
| North America | 65 (5.1) | 67 (5.2) |
| BMI, mean (SD) | 30.6 (5.0) | 30.5 (4.8) |
| Blood pressure, mean (SD), mm Hg | ||
| Systolic | 132.6 (13.9) | 134.2 (14.5) |
| Diastolic | 77.1 (10.3) | 77.3 (10.2) |
| eGFR, mean (SD), mL/min/1.73 m2 | 62.5 (20.2) | 62.7 (19.6) |
| 6-min walk distance, m | ||
| Median (IQR) | 305.0 (225.5-372.5) | 308.0 (240.0-375.0) |
| <100 | 35 (2.7) | 31 (2.4) |
| 100-450 | 1154 (90.1) | 1159 (90.2) |
| >450 | 91 (7.1) | 90 (7.0) |
| KCCQ CSS, mean (SD)c | 52.7 (16.7) | 53.3 (16.9) |
| KCCQ, mean (SD) | ||
| Total symptom score | 56.3 (18.4) | 56.6 (18.7) |
| Physical limitation score | 49.1 (19.2) | 50.0 (19.1) |
Abbreviations: BMI, body mass index, calculated as weight in kilograms divided by height in meters squared; eGFR, estimated glomerular filtration rate; KCCQ CSS, Kansas City Cardiomyopathy Questionnaire clinical summary score.
Information was collected as part of the routine demographic data; race as reported by the patients.
Includes multiaracial individuals or of any group not covered by the listed categories.
Score range, 0-100 (0, worst health; 100, excellent health). Measures quality of life of patients with HF using 7 domains: physical limitations; symptom stability, burden, and frequency; self-efficacy; quality of life; and social limitation. Physical limitations measures the limitations patients experience from HF in performing routine activities. The total symptom score comprises the symptom frequency and symptom burden domains; CSS comprises physical limitation and total symptom score.