. Author manuscript; available in PMC: 2022 Nov 1.

Published in final edited form as: Psychoneuroendocrinology. 2021 Sep 15;133:105414. doi: 10.1016/j.psyneuen.2021.105414

Table 3.

Fixed Effects Estimates from Linear Mixed Effects Models of Pathogens and Cognitive Decline in the SALSA, n=1,093

		Crude Models			IP Weighted Models			Cortisol Interaction Models
	Variable	Estimate	95%	CI	Estimate	95%	CI	Estimate	95%	CI	interaction p-value
HSV-1 IgG	Intercept	2.01	1.99	2.04	2.04	2.02	2.07	1.79	1.61	1.96
	HSV-1	−0.03	−0.06	−0.01	−0.03	−0.06	0.00	0.24	0.06	0.42
	HSV-1*Age	0.00	−0.01	0.01	0.00	−0.01	0.01	0.05	0.00	0.11
	Age	0.01	0.01	0.02	0.02	0.01	0.03	−0.04	−0.09	0.01
	Age²	0.00	0.00	0.00
	Cortisol							0.10	0.03	0.17
	Age*Cortisol							0.02	0.00	0.04
	HSV-1*Cortisol							−0.11	−0.18	−0.04	0.0028
	HSV-1AgeCortisol							−0.02	−0.04	0.00	0.046
	BIC	13983.7			13135.5			13032.2
CMV IgG	Intercept	2.02	1.99	2.05	2.04	2.01	2.06	1.74	1.57	1.92
	CMV	0.07	0.05	0.10	0.04	0.01	0.07	0.12	−0.07	0.31
	CMV*Age	0.00	−0.01	0.01	0.00	0.00	0.01	−0.04	−0.10	0.01
	Age	0.01	0.00	0.02	0.02	0.01	0.03	−0.04	−0.09	0.01
	Age²	0.00	0.00	0.00
	Cortisol							0.11	0.05	0.18
	Age*Cortisol							0.02	0.00	0.04
	CMV*Cortisol							−0.03	−0.10	0.04	0.42
	CMVAgeCortisol							0.02	0.00	0.04	0.10
	BIC	13959.3			13267.3			13172.2
VZV IgG	Intercept	2.01	1.98	2.04	2.03	2.01	2.06	1.81	1.63	1.98
	VZV	−0.05	−0.08	−0.03	−0.02	−0.05	0.01	0.02	−0.16	0.20
	VZV*Age	0.00	−0.01	0.01	0.00	−0.01	0.01	0.00	−0.06	0.05
	Age	0.01	0.01	0.02	0.02	0.01	0.03	−0.04	−0.09	0.01
	Age²	0.00	0.00	0.00
	Cortisol							0.09	0.02	0.16
	Age*Cortisol							0.02	0.00	0.04
	VZV*Cortisol							−0.01	−0.08	0.06	0.70
	VZVAgeCortisol							0.00	−0.02	0.02	0.82
	BIC	13973.4			13237.6			13145.4
H. pylori IgG	Intercept	2.01	1.99	2.04	2.04	2.02	2.07	1.74	1.57	1.92
	H. pylori	0.05	0.02	0.07	0.03	0.00	0.05	0.05	−0.13	0.23
	H. pylori*Age	−0.01	−0.02	0.00	−0.01	−0.02	0.00	−0.04	−0.10	0.02
	Age	0.01	0.01	0.02	0.02	0.01	0.03	−0.03	−0.09	0.02
	Age²	0.00	0.00	0.00
	Cortisol							0.12	0.05	0.18
	Age*Cortisol							0.02	0.00	0.04
	H. pylori*Cortisol							−0.01	−0.08	0.06	0.82
	H. pyloriAgeCortisol							0.01	−0.01	0.03	0.28
	BIC	13972.8			13160.2			13059.6
T. gondii IgG	Intercept	2.01	1.99	2.04	2.04	2.01	2.07	1.78	1.61	1.95
	T. gondii	0.05	0.02	0.08	−0.01	−0.04	0.01	−0.01	−0.18	0.15
	T. gondii*Age	0.00	−0.01	0.00	0.00	−0.01	0.03	0.00	−0.05	0.05
	Age	0.01	0.01	0.02	0.02	0.01	0.03	−0.04	−0.09	0.02
	Age²	0.00	0.00	0.00
	Cortisol							0.10	0.03	0.17
	Age*Cortisol							0.02	0.00	0.04
	T. gondii*Cortisol							0.00	−0.06	0.07	0.98
	T. gondiiAgeCortisol							0.00	−0.02	0.02	0.94
	BIC	13974.3			13198.3			13108.0