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. 2021 Jul 9;18(3):1783–1797. doi: 10.1007/s13311-021-01078-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Effect of fingolimod therapy on NK cell activation and chemotactic responses. Representative FACS plots and a histogram displaying fingolimod-induced changes over time of CCR7 (a), NKp46 (b), and DNAM-1 (c) are depicted on the left-side. Box-and-whisker plots on the right-side show the corresponding quantification for all patients at all time points. MANOVA *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; exact Wilcoxon test #p ≤ 0.05; ##p ≤ 0.01; ###p ≤ 0.001; SSC side scatter, -A pulse area, FMO fluorescence minus one, MFI median fluorescence intensity