Fig. 6.

Analysis of the effect of OEA on recognition memory along cerebellar degeneration. (a) Schematic representation of the NOR test and the objects employed. (b–e) Analyses of the percentage of time exploring familiar and novel objects at different ages for WT, PCD, and treated PCD animals; the preference for new objects is maintained in treated PCD mice until P30. (f) Chart showing the discrimination index at different ages for WT, PCD, and treated PCD mice; note that this index is similar in WT and treated PCD until P30, always resulting in a positive score greater than zero, which means there is a preference for novel objects. (g) Quantification of the number of visits to both objects at P30 and P40; no differences were observed at P30 while at P40 a decrease in the number of visits was detected in nontreated PCD. Data are represented as mean ± SEM; n = 8–9 each experimental group; Student’s t test for (b–e); one-way ANOVA followed by Bonferroni’s post hoc test for (f, g); *p < 0.05; **p < 0.01