Fig. 4.

Knocking out the DAP10 and DAP12 pathways inhibits ability the of CD200AR-L to activate CD11b cells. A CD11b cells isolated from wildtype, DAP 10, and DAP12 mice were pulsed with the CD200AR-L and incubated for 48 h. Supernatants were analyzed for TNF-alpha production by bead array. B Wildtype, C DAP12KO, and D DAP10K0 tumor-bearing mice were vaccinated with tumor lysate or CD200AR-L + tumor lysate and monitored for tumor growth and E survival. Error bars represent standard deviation, *p < 0.05, **p < 0.005, ***p < 0.0005 by t test or 2-way ANOVA