Table 4.

miRNAs as therapeutic biomarkers for ACC.

Study	Type of Study	Treatment	Post-Treatment Marker’s Level	Source	p-Value
Chabre et al., 2013 [35]	Clinical	Surgical removal	↓ miR-483-5p, ↑ miR-195	Serum	<0.05
Nagy et al., 2015 [42]	In vivo: Patient-derived xenograft in mice	Combined 9-cis retinoic acid + mitotane treatment.	↓ miR-483-5p	Serum	0.028
Jung et al., 2016 [43]	In vivo: SW-13 xenograft	LEDP-M treatment	↓ miR-210	Serum	<0.05

Upwards arrows (↑) indicate upregulation and downwards arrows (↓) indicate downregulation of miRNAs. Abbreviations: LEDP-M, etoposide, liposomal doxorubicin, liposomal cisplatin, mitotane.