Figure 4.

Effect of HCFP on mitogen-driven lymphocyte proliferation (ex-vivo) of T and B cells from healthy rats (A) and immunosuppressed rats (B) treated for 14 days with different doses of HCFP. Results were expressed in stimulation index (SI) of T and B cells as mean ± SD from six male rats (n = 5, only for high dose group of healthy rats). Control and CTX-control; water administration of 4 mL/kg. Low and high doses; HCFP soluble fraction administration of 3.08 and 6.16 mL/kg, respectively. * p < 0.05, ** p < 0.01 and *** p < 0.001 indicate significant differences between treatments and control group. Statistical significance was determined using one-way ANOVA followed by Dunnett’s multiple comparisons test.