Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 25;13(11):1785. doi: 10.3390/pharmaceutics13111785

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Cellular mechanisms of ferroptosis. The metabolic pathways involving iron, ROS, and amino acids are reported. CIP: cellular iron lipid; FT: ferritin; CRP: ceruloplasmin; TS: transferrin; TSR: transferrin receptor; FPN: ferroprotein; ACSL4: acyl-CoA synthetase long-chain family member 4; LPCAT3: lysophosphatidylcholine acyltransferase 3; ALOXs: arachidonate lipoxygenase; GPX4: glutathione peroxidase 4; ASC: alanine–serine–cysteine system; SLC7A11: solute carrier family 7 member 11; SLC3A2: solute carrier family 3 member 2; GLS: glutaminases; GSS: glutathione synthetase; GCL: glutamate-cysteine ligase; NCOA4: nuclear receptor coactivator 4; PUFAs: polyunsaturated fatty acids; FSP1: ferroptosis suppressor protein 1; TXN: thioredoxin; IREB2: iron response element binding protein 2. The figure was prepared using tools from Servier Medical Art (http://www.servier.fr/servier-medical-art, accessed on 15 September 2021).