Table 1.
Proteins identified by LC-MS/MS analysis in the secretome of hEDS myofibroblasts.
| Protein Accession N° a | Protein Name | Protein Description | Fold-Change | FDR Corrected p-Value |
|---|---|---|---|---|
| Up-regulated proteins | ||||
| P03956 | MMP1 | Matrix metalloproteinase 1 | 53.02 | 0.0016 |
| P50454 | SERPINH1 | Serpin family H member 1 | 6.19 | 0.002 |
| Q15582 | TGFBI | Transforming growth factor beta induced | 3.31 | 0.002 |
| A6XND1 | IGFBP3 | Insulin-like growth factor binding protein 3 | 3.12 | 0.024 |
| Q3BDU5 | LMNA | Lamin A/C | 2.60 | 0.003 |
| P02751 | FN1 | Fibronectin 1 | 2.44 | 0.019 |
| P09382 | LGALS1 | Galectin 1 | 2.31 | 0.001 |
| O43852 | CALU | Calumenin | 2.20 | 0.012 |
| P06733 | ENO1 | Enolase 1 | 2.14 | 0.042 |
| P11021 | HSPA5 | Heat shock protein family A (Hsp70) member 5 | 2.08 | 0.006 |
| P30101 | PDIA3 | Protein disulfide isomerase family A member 3 | 2.08 | 0.036 |
| Q07954 | LRP1 | LDL receptor related protein 1 | 2.07 | 0.002 |
| F6SYF8 | DKK3 | Dickkopf WNT signaling pathway inhibitor 3 | 2.04 | 0.041 |
| P07686 | HEXB | Hexosaminidase subunit beta | 1.90 | <0.001 |
| P12111 | COL6A3 | Collagen type VI alpha 3 chain | 1.61 | 0.029 |
| C9JIZ6 | PSAP | Prosaposin | 1.60 | 0.002 |
| Q8NBS9 | TXNDC5 | Thioredoxin domain containing 5 | 1.54 | 0.003 |
| P07237 | P4HB | Prolyl 4-hydroxylase subunit beta | 1.53 | 0.016 |
| Q02818 | NUCB1 | Nucleobindin 1 | 1.52 | 0.022 |
| P23528 | CFL1 | Cofilin 1 | 1.44 | 0.023 |
| P23284 | PPIB | Peptidylprolyl isomerase B | 1.40 | 0.040 |
| Down-regulated proteins | ||||
| P35442 | THBS2 | Thrombospondin 2 | 0.76 | 0.008 |
| P02452 | COL1A1 | Collagen type I alpha 1 chain | 0.71 | 0.010 |
| P98160 | HSPG2 | Heparan sulfate proteoglycan 2 | 0.67 | 0.031 |
| P18206 | VCL | Vinculin | 0.65 | 0.014 |
| O14498 | ISLR | Immunoglobulin superfamily containing leucine rich repeat | 0.64 | 0.012 |
| P61769 | B2M | Beta-2-microglobulin | 0.63 | 0.021 |
| P16035 | TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.63 | 0.015 |
| P26022 | PTX3 | Pentraxin 3 | 0.59 | 0.004 |
| P02461 | COL3A1 | Collagen type III alpha 1 chain | 0.56 | 0.003 |
| P05155 | SERPING1 | Serpin family G member 1 | 0.56 | 0.012 |
| P05997 | COL5A2 | Collagen type V alpha 2 chain | 0.42 | 0.001 |
a Protein accession number according to the UniProtKB knowledgebase database (last access on 15 October 2021).