Table 2.
Concentration–response curves for the CP 55,940-stimulated specific [35S]GTPγS binding in vehicle (control) or MβCD pretreated frontal cortical synaptosomes derived from Glu-CB1-RS and GABA-CB1-RS mice. Values correspond to the means ± SEM of three independent experiments performed in triplicate, using synaptosomes enriched preparations obtained from a pool of the frontal cortices of eight adult mice. Unpaired (%Emax) or paired (pEC50, Basal) two-tailed t-test.
| Glu-CB1-RS | GABA-CB1-RS | |||
|---|---|---|---|---|
| Control | MβCD | Control | MβCD | |
| %Emax | 170.95 ± 3.23 | 225.87 ± 8.75 * | 167.43 ± 9.17 | 217 ± 14.20 * |
| pEC50 | 6.61 ± 0.12 | 6.78 ± 0.06 | 7.02 ± 0.08 | 6.96 ± 0.13 |
| Basal (cpm) | 11,175 ± 264 | 7443 ± 267 * | 10,324 ± 457 | 8696 ± 95 |
* = significantly different from control, p < 0.05.