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Function of LSD1 in reprogramming. LSD1 depletion by tranylcypromine, lithium, GSK3β or shRNA promotes iPSC reprogramming by two different pathways. Firstly, LSD1 inhibition enhances the exogenous expression of the Yamanaka factors, stimulating the conversion of fibroblast to pre-iPSC. Secondly, LSD1 inhibition leads to a metabolic switch from oxidative phosphorylation to glycolysis by rescuing Hif1α expression which promotes the conversion from pre-iPSC to iPSC [108].
