Figure 3.

In vivo screening of Luc mRNA delivery. Top functionalized polyesters were examined for their ability to deliver Luc mRNA in vivo. C57BL/6 mice were randomly grouped and intravenously injected with 0.5 mg/kg Luc mRNA (n = 2). Luminescence was quantified 6 h after injection. (A) Ex vivo bioluminescence images of selected polyesters. The yellow triangle denotes detector saturation of signals. (B,C) The average luminescence for the spleen and lungs was plotted. The parent polyester was PE4K-A17 for all the above selected functionalized polyesters (mean ± s.d., n = 2, p < 0.05 (*)).