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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Hepatology. 2021 Mar 16;73(5):1701–1716. doi: 10.1002/hep.31517

Figure 2. Hsd17b13 deficiency induces weight gain in mice fed regular chow diet.

Figure 2.

Eight week-old male wild type (WT) and Hsd17b13-knockout (KO) mice were fed regular chow for 12 weeks and sacrified at age 20 weeks, after a 5 hours fast. (A) Body weight of WT and KO mice was measured weekly. (B) Body weight, (C) Lean mass relative to body weight, and (D) Fat mass relative to body weight. (E) Liver weight, (F) Liver-to-body weight ratio, and (G) Liver triglycerides. (H) Hematoxylin & eosin staining of liver sections. Bar indicates 100 μM. (I) Hepatic gene expression, normalized to WT level. Hsd17b13 1–3 and 6–7 denotes two separate regions in the gene. N=6 male mice per group. B-I assessed at sacrifice at age 20 weeks. Mean±SEM; *p<0.05, ****p<0.0001