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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Hepatology. 2021 Mar 16;73(5):1701–1716. doi: 10.1002/hep.31517

Figure 3. Limited impact of Hsd17b13 deficiency on high fat diet (HFD) liver injury.

Figure 3.

Eight week-old male wild type (WT) and Hsd17b13-knockout (KO) mice were fed with HFD for 12 weeks and sacrified at age 20 weeks after a 5 hours fast. (A) Weekly body weight measurements, (B) Liver weights, (C) Liver triglycerides, and (D) Serum alanine aminotransferase (ALT). (E) Hematoxylin & eosin staining of liver sections. Bar indicates 100 μM. (F) Percentage of steatotic hepatocytes. (G) Percentage of macro- and microtsteatotic hepatocytes. (H) Histological inflammation score. (I) Hepatic collagen content by Sirus Red staining (left) or colorimetric assay (right). Arrow indicates representive positive staining. Bar indicates 100 μM. (J) Serum cholesterol, (K) Serum triglycerides, (L) Serum free fatty acids, and (M) Blood glucose. (N) Hepatic gene expression level of fibrosis- and inflammation-related genes. N=6 male mice per group. B-N assessed at sacrifice at age 20 weeks. Mean±SEM; *p<0.05, **p<0.01