Abstract
This correspondence discussed on published article on “thromboses of major arteries and ChAdOx1 nCov-19 vaccination”.
Keywords: Thromboses, Cov-19, Vaccination
Dear Editor, we would like to share ideas on the publication “Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination [1].” Zarrouk and Finsterer concluded that “Both were successfully treated with intravenous immunoglobulins and non-heparin anticoagulant agents …. in case 1 and four months in case 2. [1].” Thrombosis might occur in post COVID-19 vaccination. In the present case, the pathogenesis is still unclear. A possible mechanism in the present case is hyperviscosity following vaccination [2]. This is due to rapid change of blood viscosity due to immunogenicity process of COVID-19 vaccine [2]. The successful of treatment by non-heparin anticoagulant agents can support that the main pathological problem is not on coagulation component and platelet but plasma viscosity. Additionally, when there is a decline in stimulation, a decreased blood viscosity occurs and it is concordant with the observation that the patients improved within 6 weeks.
Acknowledgements
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Abbreviation
- COVID-19
Coronavirus disease 2019
Authors' contributions
RM: 50% ideas, drafting, writing, final approval for submission. VW: 50% ideas, supervising, final approval for submission. Both authors read and approved the final manuscript.
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Consent.
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The authors declare that they have no competing interests.
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References
- 1.Goereci Y, Kleineberg NN, Madlener M, Neuschmelting H, Fink GR, Warnke C, Stetefeld H. Successful treatment of thromboses of major arteries after ChAdOx1 nCov-19 vaccination. Neurological Research and Practice. 2021;3(1):52. doi: 10.1186/s42466-021-00151-y. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Joob B, Wiwanitkit V. Expected viscosity after COVID-19 vaccination, hyperviscosity and previous COVID-19. Clinical and Applied Thrombosis/Hemostasis. 2021;27:10760296211020833. doi: 10.1177/10760296211020833. [DOI] [PMC free article] [PubMed] [Google Scholar]
Associated Data
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Data Availability Statement
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